You Tongjian, Nicklas Barbara J
Department of Exercise and Nutrition Sciences, School of Public Health and Health Professions, State University of New York at Buffalo, Buffalo, NY 14214, USA.
Curr Diab Rep. 2008 Feb;8(1):7-11. doi: 10.1007/s11892-008-0003-4.
Adipokines, or adipose tissue-derived cytokines/proteins, may be important factors linking excess adipose tissue to individual metabolic risk factors, and the overall metabolic syndrome. Current evidence supports that aerobic exercise, alone or combined with hypocaloric diet, improves symptoms of the metabolic syndrome, possibly by altering systemic levels of inflammatory adipokines. A number of studies show that increased physical activity leads to lower circulating levels of proinflammatory cytokines and higher levels of adiponectin. However, limited data show that exercise training does not influence adipose tissue adipokine expression or release. Conversely, exercise training may influence cytokine production by circulating mononuclear cells, another important source of elevated inflammation. Future studies are needed to investigate the cellular mechanisms by which exercise training affects inflammation and whether alterations in inflammation are one mechanism by which exercise improves components of the metabolic syndrome in at-risk individuals.
脂肪因子，即脂肪组织衍生的细胞因子/蛋白质，可能是将过多脂肪组织与个体代谢风险因素以及整体代谢综合征联系起来的重要因素。目前的证据支持，有氧运动单独或与低热量饮食相结合，可能通过改变全身性炎症脂肪因子水平来改善代谢综合征的症状。多项研究表明，增加身体活动会导致促炎细胞因子的循环水平降低，脂联素水平升高。然而，有限的数据表明运动训练不会影响脂肪组织中脂肪因子的表达或释放。相反，运动训练可能会影响循环单核细胞产生细胞因子，而循环单核细胞是炎症加剧的另一个重要来源。未来需要开展研究，以探究运动训练影响炎症的细胞机制，以及炎症改变是否是运动改善高危个体代谢综合征各组成部分的一种机制。
