Khachatrian S A, Khachatrian K A
Biull Eksp Biol Med. 1977 Nov;84(11):544-7.
The lipolytic activity in the adipose tissue, unesterified fatty acids (UFA) in the blood and adipose tissue, as well as ketone bodies and beta-lipoproteins in the blood were determined in dogs during dying of acute blood loss and the restorative period after the revival of the organism. During agony the activation of lipolysis in the adipose tissue, a decrease of UFA and beta-lipoproteins and an increase of ketane bodies contents in the blood were detected. At the end of the third minute of clinical death there occurred a depression of lipolysis and an increase of UFA content in the adipose tissue. One hour after the revival of the organism the blood UFA content and beta-proteins decrease, but the ketone bodies content rises; simultaneously there occurs some reduction of lipolytic activity of the adipose tissue. At the late postreanimation period (in 1, 3, and 7 days) an activation of lipolysis in the adipose tissue and an increase of UFA, ketone bodies, and beta-lipoproteins content in the blood was noted. The adipose tissue UFA content was low during the postreanimation period. The given results have shown that the changes in the lipid metabolism could play some role in the pathogenesis of non-reversibility during dying and after the revival of the organism.
在急性失血濒死期及机体复苏后的恢复期，对犬的脂肪组织中的脂解活性、血液及脂肪组织中的未酯化脂肪酸（UFA）、血液中的酮体及β-脂蛋白进行了测定。在濒死期，检测到脂肪组织中脂解作用激活、血液中UFA和β-脂蛋白减少以及酮体含量增加。临床死亡第三分钟末，脂肪组织中脂解作用受抑制，UFA含量增加。机体复苏一小时后，血液中UFA含量和β-蛋白减少，但酮体含量升高；同时，脂肪组织的脂解活性有所降低。在复苏后期（1、3和7天），发现脂肪组织中脂解作用激活，血液中UFA、酮体和β-脂蛋白含量增加。复苏期脂肪组织中UFA含量较低。上述结果表明，脂质代谢变化在机体濒死期及复苏后不可逆性发病机制中可能起一定作用。
