Chirskiĭ V S, Zhdanov K V, Gusev D A, Alent'ev G A
Arkh Patol. 2009 Nov-Dec;71(6):29-32.
Pathomorphological changes were analyzed in the HCV-cirrhotic liver of patients with varying decompensation of the organ 's function. The decompensation of liver function in HCV cirrhosis was shown to be directly related to the infectious process. It is conceivable that it is to a greater degree determined by an autoimmune response, as confirmed by lower blood virus replicative activity, NS3 protein expression in the cells of an inflammatory infiltrate in the portal tract, and reduced detection rates for NS3 protein expression in the hepatocytic cytoplasm as the pathological process progresses.
对器官功能失代偿程度不同的丙型肝炎肝硬化患者的肝脏进行了病理形态学分析。结果显示，丙型肝炎肝硬化患者的肝功能失代偿与感染过程直接相关。可以想象，这在很大程度上是由自身免疫反应决定的，这一点可通过血液中病毒复制活性降低、门静脉炎症浸润细胞中NS3蛋白表达以及随着病理过程进展肝细胞质中NS3蛋白表达检测率降低得到证实。
