多米诺 Heck-aza-Michael 反应：高效构建 1-取代四氢-β-咔啉。
Domino Heck-aza-Michael reactions: efficient access to 1-substituted tetrahydro-beta-carbolines.
机构信息
School of Life and Environmental Science, Deakin University, Geelong 3217, Victoria, Australia.
出版信息
J Org Chem. 2010 Mar 5;75(5):1787-90. doi: 10.1021/jo902652h.
PMID:20131765
Abstract
A simple and efficient palladium-catalyzed domino reaction for the synthesis of a series of C1-substituted tetrahydro-beta-carbolines is described. This domino process involves a Heck reaction at the indole 2-position of a halogenated tryptamine precursor, followed by intramolecular aza-Michael addition.
摘要
描述了一种简单高效的钯催化的串联反应，用于合成一系列 C1 取代的四氢-β-咔啉。该串联过程涉及卤代色胺前体吲哚 2-位的 Heck 反应，随后是分子内氮杂-Michael 加成。
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