通过钯催化的分子内烯丙基烷基化反应实现四氢-β-咔啉和四氢-γ-咔啉的高度对映选择性合成。
Highly enantioselective synthesis of tetrahydro-beta-carbolines and tetrahydro-gamma-carbolines via Pd-catalyzed intramolecular allylic alkylation.
作者信息
Bandini Marco, Melloni Alfonso, Piccinelli Fabio, Sinisi Riccardo, Tommasi Simona, Umani-Ronchi Achille
机构信息
Dipartimento di Chimica "G. Ciamician", Alma Mater Studiorum, Università di Bologna, via Selmi 2, 40126 Bologna, Italy.
出版信息
J Am Chem Soc. 2006 Feb 8;128(5):1424-5. doi: 10.1021/ja054109o.
PMID:16448093
Abstract
A novel Pd-catalyzed intramolecular allylic alkylation of indoles allows THBCs and THGCs to be effectively synthesized in high yields and excellent enantiomeric excesses (ee up to 97%).
摘要
一种新型的钯催化吲哚分子内烯丙基烷基化反应能够以高产率和优异的对映体过量（对映体过量高达97%）有效地合成THBCs和THGCs。
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