Addiction Research Institute, The University of Texas at Austin, Austin, Texas 78703, USA.
Am J Addict. 2010 Jan-Feb;19(1):73-88. doi: 10.1111/j.1521-0391.2009.00008.x.
Abuse of prescription opioids is a growing problem. The number of methadone pain pills distributed now exceeds liquid methadone used in opioid treatment, and the increases in buprenorphine indicators provide evidence of the need to monitor and intervene to decrease the abuse of this drug. The need for additional and improved data to track trends is discussed, along with findings as to the characteristics of the users and combinations of drugs. Data on toxicities related to methadone or buprenorphine, particularly in combination with other prescribed drugs, are presented and clinical implications and considerations are offered. These findings underscore the need for physicians to be aware of potential toxicities and to educate their patients regarding these issues.
处方类阿片类药物滥用是一个日益严重的问题。现在发放的美沙酮止痛药片数量超过了阿片类药物治疗中使用的液体美沙酮，丁丙诺啡指标的增加表明有必要进行监测和干预，以减少这种药物的滥用。文中讨论了对额外和改进数据的需求，以跟踪趋势，并提供了有关使用者特征和药物组合的发现。本文还介绍了与美沙酮或丁丙诺啡相关的毒性数据，特别是与其他处方药物联合使用时的毒性数据，并提出了临床意义和考虑因素。这些发现强调了医生需要意识到潜在的毒性，并就这些问题对患者进行教育。
