美沙酮和丁丙诺啡使用和滥用的指标：我们了解多少？
Indicators of buprenorphine and methadone use and abuse: what do we know?
机构信息
Addiction Research Institute, The University of Texas at Austin, Austin, Texas 78703, USA.
出版信息
Am J Addict. 2010 Jan-Feb;19(1):73-88. doi: 10.1111/j.1521-0391.2009.00008.x.
Abstract
Abuse of prescription opioids is a growing problem. The number of methadone pain pills distributed now exceeds liquid methadone used in opioid treatment, and the increases in buprenorphine indicators provide evidence of the need to monitor and intervene to decrease the abuse of this drug. The need for additional and improved data to track trends is discussed, along with findings as to the characteristics of the users and combinations of drugs. Data on toxicities related to methadone or buprenorphine, particularly in combination with other prescribed drugs, are presented and clinical implications and considerations are offered. These findings underscore the need for physicians to be aware of potential toxicities and to educate their patients regarding these issues.
摘要
处方类阿片类药物滥用是一个日益严重的问题。现在发放的美沙酮止痛药片数量超过了阿片类药物治疗中使用的液体美沙酮，丁丙诺啡指标的增加表明有必要进行监测和干预，以减少这种药物的滥用。文中讨论了对额外和改进数据的需求，以跟踪趋势，并提供了有关使用者特征和药物组合的发现。本文还介绍了与美沙酮或丁丙诺啡相关的毒性数据，特别是与其他处方药物联合使用时的毒性数据，并提出了临床意义和考虑因素。这些发现强调了医生需要意识到潜在的毒性，并就这些问题对患者进行教育。
相似文献
1
Indicators of buprenorphine and methadone use and abuse: what do we know?美沙酮和丁丙诺啡使用和滥用的指标：我们了解多少？
Am J Addict. 2010 Jan-Feb;19(1):73-88. doi: 10.1111/j.1521-0391.2009.00008.x.
2
Drug interactions of clinical importance among the opioids, methadone and buprenorphine, and other frequently prescribed medications: a review.阿片类药物、美沙酮和丁丙诺啡之间具有临床重要意义的药物相互作用，以及其他经常开处方的药物：综述。
Am J Addict. 2010 Jan-Feb;19(1):4-16. doi: 10.1111/j.1521-0391.2009.00005.x.
3
Opioid-related mortality and filled prescriptions for buprenorphine and methadone.与阿片类药物相关的死亡率以及丁丙诺啡和美沙酮的处方量。
Drug Alcohol Rev. 2014 Sep;33(5):491-8. doi: 10.1111/dar.12143. Epub 2014 Apr 16.
4
Methadone and buprenorphine toxicity in children.儿童美沙酮和丁丙诺啡中毒。
Am J Addict. 2010 Jan-Feb;19(1):89-95. doi: 10.1111/j.1521-0391.2009.00002.x.
5
Non-prescribed use of opioid substitution medication: Patterns and trends in sub-populations of opioid users in Germany.阿片类替代药物的非处方使用：德国阿片类药物使用者亚群体的模式与趋势
Int J Drug Policy. 2016 Mar;29:57-65. doi: 10.1016/j.drugpo.2015.12.024. Epub 2015 Dec 31.
6
Intravenous Misuse of Methadone, Buprenorphine and Buprenorphine-Naloxone in Patients Under Opioid Maintenance Treatment: A Cross-Sectional Multicentre Study.静脉内滥用美沙酮、丁丙诺啡和丁丙诺啡-纳洛酮在接受阿片类药物维持治疗的患者中的横断面多中心研究。
Eur Addict Res. 2019;25(1):10-19. doi: 10.1159/000496112. Epub 2019 Jan 9.
7
[Interactions with methadone and buprenorphine].[与美沙酮和丁丙诺啡的相互作用]
Tidsskr Nor Laegeforen. 2009 Nov 19;129(22):2364-6. doi: 10.4045/tidsskr.09.0471.
8
Illicit use of methadone and buprenorphine among adolescents and young adults in Sweden.瑞典青少年和年轻成年人中非法使用美沙酮和丁丙诺啡。
Harm Reduct J. 2013 Oct 18;10:27. doi: 10.1186/1477-7517-10-27.
9
Opioids and the management of chronic severe pain in the elderly: consensus statement of an International Expert Panel with focus on the six clinically most often used World Health Organization Step III opioids (buprenorphine, fentanyl, hydromorphone, methadone, morphine, oxycodone).阿片类药物与老年人慢性重度疼痛的管理：一个国际专家小组的共识声明，重点关注世界卫生组织第三阶梯临床最常用的六种阿片类药物（丁丙诺啡、芬太尼、氢吗啡酮、美沙酮、吗啡、羟考酮）。
Pain Pract. 2008 Jul-Aug;8(4):287-313. doi: 10.1111/j.1533-2500.2008.00204.x. Epub 2008 May 23.
10
Less driving impairment on buprenorphine than methadone in drug-dependent patients?在药物依赖患者中，丁丙诺啡导致的驾驶功能损害是否比美沙酮少？
J Neuropsychiatry Clin Neurosci. 2001 Fall;13(4):527-8. doi: 10.1176/jnp.13.4.527.
引用本文的文献
1
Unique pharmacodynamic properties and low abuse liability of the µ-opioid receptor ligand (S)-methadone.（S）-美沙酮作为μ-阿片受体配体具有独特的药效学特性和较低的滥用倾向。
Mol Psychiatry. 2024 Mar;29(3):624-632. doi: 10.1038/s41380-023-02353-z. Epub 2023 Dec 25.
2
Ketogenic diet enhances the effects of oxycodone in mice.生酮饮食增强了羟考酮在小鼠体内的作用。
Sci Rep. 2023 May 9;13(1):7507. doi: 10.1038/s41598-023-33458-8.
3
Changes in Buprenorphine and Methadone Supplies in the US During the COVID-19 Pandemic.在 COVID-19 大流行期间美国丁丙诺啡和美沙酮供应的变化。
JAMA Netw Open. 2022 Jul 1;5(7):e2223708. doi: 10.1001/jamanetworkopen.2022.23708.
4
Supporting individuals using medications for opioid use disorder in recovery residences: challenges and opportunities for addressing the opioid epidemic.支持在康复住所中使用药物治疗阿片类药物使用障碍的个人：解决阿片类药物流行的挑战和机遇。
Am J Drug Alcohol Abuse. 2020 May 3;46(3):266-272. doi: 10.1080/00952990.2020.1719410. Epub 2020 Feb 24.
5
Can neuroimaging help combat the opioid epidemic? A systematic review of clinical and pharmacological challenge fMRI studies with recommendations for future research.神经影像学能否有助于对抗阿片类药物泛滥？一项针对临床和药理学挑战 fMRI 研究的系统评价及对未来研究的建议。
Neuropsychopharmacology. 2019 Jan;44(2):259-273. doi: 10.1038/s41386-018-0232-4. Epub 2018 Oct 3.
6
Treatment of Chronic Hepatitis C in Patients Receiving Opioid Agonist Therapy: A Review of Best Practice.慢性丙型肝炎患者接受阿片类激动剂治疗的治疗：最佳实践综述。
Infect Dis Clin North Am. 2018 Jun;32(2):347-370. doi: 10.1016/j.idc.2018.02.001.
7
Management of opioid use disorders: a national clinical practice guideline.阿片类物质使用障碍的管理：一项国家临床实践指南。
CMAJ. 2018 Mar 5;190(9):E247-E257. doi: 10.1503/cmaj.170958.
8
Abuse liability of intravenous buprenorphine vs. buprenorphine/naloxone: Importance of absolute naloxone amount.静脉注射丁丙诺啡与丁丙诺啡/纳洛酮的滥用可能性：绝对纳洛酮剂量的重要性。
Drug Alcohol Depend. 2017 Oct 1;179:362-369. doi: 10.1016/j.drugalcdep.2017.06.033. Epub 2017 Jul 26.
9
Low-dose naloxone provides an abuse-deterrent effect to buprenorphine.低剂量纳洛酮可对丁丙诺啡产生抗滥用作用。
J Pain Res. 2015 Nov 4;8:791-8. doi: 10.2147/JPR.S90780. eCollection 2015.
10
Pharmacokinetics of Sublingual Buprenorphine and Naloxone in Subjects with Mild to Severe Hepatic Impairment (Child-Pugh Classes A, B, and C), in Hepatitis C Virus-Seropositive Subjects, and in Healthy Volunteers.轻度至重度肝功能损害（Child-Pugh A、B和C级）受试者、丙型肝炎病毒血清学阳性受试者及健康志愿者中舌下含服丁丙诺啡和纳洛酮的药代动力学
Clin Pharmacokinet. 2015 Aug;54(8):837-49. doi: 10.1007/s40262-015-0238-6.
本文引用的文献
1
Benzodiazepines, methadone and buprenorphine: interactions and clinical management.苯二氮䓬类药物、美沙酮和丁丙诺啡：相互作用和临床管理。
Am J Addict. 2010 Jan-Feb;19(1):59-72. doi: 10.1111/j.1521-0391.2009.00007.x.
2
Increase in fatal poisonings involving opioid analgesics in the United States, 1999-2006.1999 - 2006年美国涉及阿片类镇痛药的致命中毒事件增加。
NCHS Data Brief. 2009 Sep(22):1-8.
3
Patterns of abuse among unintentional pharmaceutical overdose fatalities.非故意药物过量致死案例中的滥用模式。
JAMA. 2008 Dec 10;300(22):2613-20. doi: 10.1001/jama.2008.802.
4
Benzodiazepine use among opiate-dependent subjects in buprenorphine maintenance treatment: correlates of use, abuse and dependence.丁丙诺啡维持治疗中阿片类药物依赖者使用苯二氮䓬类药物的情况：使用、滥用及依赖的相关因素
Drug Alcohol Depend. 2009 Jan 1;99(1-3):338-44. doi: 10.1016/j.drugalcdep.2008.07.017. Epub 2008 Sep 27.
5
Opioid pharmacology.阿片类药物药理学
Pain Physician. 2008 Mar;11(2 Suppl):S133-53.
6
Methadone- and heroin-related deaths in Florida.佛罗里达州与美沙酮和海洛因相关的死亡案例。
Am J Drug Alcohol Abuse. 2008;34(3):347-53. doi: 10.1080/00952990802010892.
7
An in vitro approach to potential methadone metabolic-inhibition interactions.一种针对潜在美沙酮代谢抑制相互作用的体外研究方法。
Eur J Clin Pharmacol. 2007 Sep;63(9):821-7. doi: 10.1007/s00228-007-0327-z. Epub 2007 Jun 28.
8
Increased (R)-methadone plasma concentrations by quetiapine in cytochrome P450s and ABCB1 genotyped patients.在细胞色素P450和ABCB1基因分型患者中，喹硫平使（R）-美沙酮血浆浓度升高。
J Clin Psychopharmacol. 2007 Jun;27(3):273-8. doi: 10.1097/JCP.0b013e3180592ad2.
9
Concurrent buprenorphine and benzodiazepines use and self-reported opioid toxicity in opioid substitution treatment.丁丙诺啡与苯二氮䓬类药物联合使用及阿片类药物替代治疗中自我报告的阿片类药物毒性
Addiction. 2007 Apr;102(4):616-22. doi: 10.1111/j.1360-0443.2006.01731.x. Epub 2007 Feb 6.
10
Pharmacogenetics and drug therapy in psychiatry--the role of the CYP2D6 polymorphism.精神药理学中的药物遗传学与药物治疗——CYP2D6基因多态性的作用
Curr Pharm Des. 2007;13(2):241-50. doi: 10.2174/138161207779313704.
Zotero 插件