Department of Emergency Medicine, Division of Medical Toxicology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
Am J Addict. 2010 Jan-Feb;19(1):89-95. doi: 10.1111/j.1521-0391.2009.00002.x.
Recent years have seen very large increases in the prescribing of methadone and buprenorphine formulations for treatment of opioid addiction as well as the increasing utilization of methadone for the treatment of chronic pain. Coincident with the rise in the prescribing of these drugs has been a substantial increase in pediatric opioid toxicities and adverse events. This review will address the current state of methadone- and buprenorphine-related adverse events in children in the United States. We will also discuss treatment of opioid toxicity in pediatric populations and make recommendations aimed at reducing these occurrences.
近年来，美沙酮和丁丙诺啡制剂的处方量大幅增加，用于治疗阿片类药物成瘾，以及美沙酮用于治疗慢性疼痛的使用也不断增加。这些药物的处方量增加的同时，儿童阿片类药物中毒和不良事件也大幅增加。本综述将讨论目前美国儿童中美沙酮和丁丙诺啡相关不良事件的现状。我们还将讨论儿科人群中阿片类药物中毒的治疗，并提出旨在减少这些事件发生的建议。
