Division of General Internal Medicine, Albert Einstein College of Medicine, Montefiore Medical Center, 3300 Kossuth Avenue, Bronx, NY 10467, USA.
Division of General Internal Medicine, Albert Einstein College of Medicine, Montefiore Medical Center, 3300 Kossuth Avenue, Bronx, NY 10467, USA.
Infect Dis Clin North Am. 2018 Jun;32(2):347-370. doi: 10.1016/j.idc.2018.02.001.
Injection drug use is the most common transmission route for hepatitis C. High rates of infection are observed among individuals on opioid agonist therapy. Although people who inject drugs carry the highest burden, few have initiated treatment. We present a comprehensive review of the evidence on the efficacy of HCV medications, drug-drug interactions, and barriers to and models of care. Studies have demonstrated comparable efficacy for individuals who are on opioid agonist therapy compared with those who are not. We propose that a strategy of treatment and cure-as-prevention is imperative in this population to curb the hepatitis C epidemic.
注射毒品是丙型肝炎最常见的传播途径。阿片类药物激动剂治疗者的感染率很高。尽管注射毒品者负担最重，但接受治疗的人却很少。我们全面回顾了丙型肝炎药物的疗效、药物相互作用以及治疗障碍和模式的证据。研究表明，接受阿片类药物激动剂治疗的个体与未接受治疗的个体相比，药物疗效相当。我们提出，在这一人群中，必须采取治疗和治愈即预防的策略，以遏制丙型肝炎的流行。
