Vernon R G
Hannah Research Institute, Ayr, Scotland, U.K.
Domest Anim Endocrinol. 1991 Jan;8(1):161-4. doi: 10.1016/0739-7240(91)90050-t.
Chronic endocrine control of fatty acid synthesis in perirenal and subcutaneous adipose tissues of foetal lambs has been investigated. Maintenance of explants of subcutaneous adipose tissue in culture for 48 hr with insulin and dexamethasone (a glucocorticoid analogue), either singly or in combination showed that the two acted synergistically to increase the rate of fatty acid synthesis. Growth hormone inhibited the ability of insulin plus dexamethasone to increase the rate of fatty acid synthesis in explants of subcutaneous adipose tissue. In contrast neither insulin nor dexamethasone either singly or together increased the rate of fatty acid synthesis in perirenal adipose tissue; growth hormone also had no effect on the rate of fatty acid synthesis in this depot. These studies show that fatty acid synthesis is under distinct endocrine control in subcutaneous and perirenal adipose tissues in foetal lambs.
对胎羊肾周和皮下脂肪组织中脂肪酸合成的慢性内分泌控制进行了研究。将皮下脂肪组织外植体在含有胰岛素和地塞米松（一种糖皮质激素类似物）的培养基中单独或联合培养48小时，结果表明二者协同作用可提高脂肪酸合成速率。生长激素抑制胰岛素加地塞米松提高皮下脂肪组织外植体中脂肪酸合成速率的能力。相比之下，胰岛素和地塞米松单独或共同作用均未提高肾周脂肪组织中脂肪酸的合成速率；生长激素对该脂肪库中脂肪酸的合成速率也没有影响。这些研究表明，胎羊皮下和肾周脂肪组织中脂肪酸的合成受不同的内分泌控制。
