Kohada A, Miyake Y, Sugai M, Tsuru H, Suginaka H
Department of Microbiology, Hiroshima University School of Dentistry, Japan.
Chemotherapy. 1991;37(1):50-6. doi: 10.1159/000238832.
We investigated the effects of several antibiotics on the adherence of Staphylococcus aureus FDA 209P to polymorphonuclear leukocytes. Sublethal concentrations of aminoglycosides enhanced staphylococcal adherence to polymorphonuclear leukocytes, whereas beta-lactams, minocycline, ofloxacin and clindamycin decreased the adherence. Chloramphenicol and rokitamycin had no effect. It is likely that the adherence following antibiotic treatment is related to cell surface hydrophobicity determined by the measurement of the contact angle of 1-bromonaphthalene on a monolayer of staphylococcal cells.
我们研究了几种抗生素对金黄色葡萄球菌FDA 209P黏附多形核白细胞的影响。亚致死浓度的氨基糖苷类抗生素增强了葡萄球菌对多形核白细胞的黏附，而β-内酰胺类抗生素、米诺环素、氧氟沙星和克林霉素则降低了黏附。氯霉素和罗他霉素没有影响。抗生素治疗后的黏附可能与通过测量1-溴萘在葡萄球菌细胞单层上的接触角所确定的细胞表面疏水性有关。
