Van der Auwera P, Husson M, Frühling J
Service de Médecine et Laboratoire d'Investigation Clinique H.J. Tagnon, Brussels, Belgium.
J Antimicrob Chemother. 1987 Sep;20(3):399-404. doi: 10.1093/jac/20.3.399.
The influence of several new antibiotics on phagocytosis of two strains of Staphylococcus aureus by human polymorphonuclear leucocytes was studied with a radioisotopic method. The following antibiotics were tested in concentrations obtained in the serum after standard administration: gentamicin, netilmicin, amikacin, oxacillin, clindamycin, vancomycin, teicoplanin, rifampicin, ansamycin, coumermycin, enoxacin, ciprofloxacin, two new fluoro-quinolones CI 934 and RO 236240, and LY 146032 a new lipopeptidic antibiotic. Among them, only coumermycin significantly decreased phagocytosis, this was dependent on concentration, strain and source of the polymorphonuclear leucocytes.
采用放射性同位素方法研究了几种新型抗生素对人多形核白细胞吞噬两株金黄色葡萄球菌的影响。对以下抗生素进行了测试，其浓度为标准给药后血清中获得的浓度：庆大霉素、奈替米星、阿米卡星、苯唑西林、克林霉素、万古霉素、替考拉宁、利福平、安莎霉素、香豆霉素、依诺沙星、环丙沙星、两种新型氟喹诺酮类药物CI 934和RO 236240，以及新型脂肽类抗生素LY 146032。其中，只有香豆霉素显著降低了吞噬作用，这取决于多形核白细胞的浓度、菌株和来源。
