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在单相和双相情感障碍中报告的不良生活事件和最严重的疾病发作:测量遗传研究的环境风险。

Adverse life event reporting and worst illness episodes in unipolar and bipolar affective disorders: measuring environmental risk for genetic research.

机构信息

MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK.

出版信息

Psychol Med. 2010 Nov;40(11):1829-37. doi: 10.1017/S003329170999225X. Epub 2010 Feb 5.

Abstract

BACKGROUND

Studies exploring gene-environment interplay in affective disorders now include very large numbers of participants. Methods for evaluating the role of adversity in such studies need to be developed that do not rely on lengthy and labour-intensive interviews. In the present study, a brief questionnaire method for measuring 11 adverse events reported before interview and before their worst illness episodes by bipolar, unipolar and healthy control participants, participating in genetic association studies, was evaluated.

METHOD

Five hundred and twelve bipolar disorder (BD) participants, 1447 participants with recurrent unipolar depression (UPD) and 1346 psychiatrically healthy control participants underwent the researcher-administered version of the List of Threatening Experiences Questionnaire (LTE-Q) for the 6 months before their worst affective episodes for UPD and BD participants, and for the 6 months before interview for the UPD participants and controls.

RESULTS

UPD and BD cases were significantly more likely to report at least one event, as well as more events in the 6 months before interview and before their worst illness episodes, than healthy controls. Both manic and depressive episodes were significantly associated with adverse events in the BD cases. Depressed mood at the time of interview influenced event reporting in UPD and control participants but not the BD cases. Age was negatively correlated with the number of events reported by controls.

CONCLUSIONS

The researcher-administered LTE-Q provides a measure of case-control differences for adversity that is applicable in large genetic association studies. Confounding factors for event reporting include present mood and age.

摘要

背景

目前,探索情感障碍中基因-环境相互作用的研究已经纳入了大量的参与者。需要开发评估逆境在这些研究中作用的方法,这些方法不应依赖于冗长而劳动密集型的访谈。在本研究中,我们评估了一种通过双相情感障碍、单相情感障碍和健康对照组参与者在基因关联研究中参与的简短问卷方法来测量 11 种在访谈前和最严重疾病发作前报告的不良事件。

方法

512 名双相情感障碍(BD)参与者、1447 名复发性单相情感障碍(UPD)参与者和 1346 名心理健康对照组参与者接受了研究者管理的威胁经历清单问卷(LTE-Q)的版本,用于 UPD 和 BD 参与者的最严重情感发作前的 6 个月,以及 UPD 参与者和对照组的访谈前 6 个月。

结果

与健康对照组相比,UPD 和 BD 病例更有可能报告至少一次事件,以及在访谈前和最严重疾病发作前的 6 个月内发生更多事件。BD 病例的躁狂和抑郁发作均与不良事件显著相关。访谈时的抑郁情绪影响 UPD 和对照组参与者的事件报告,但不影响 BD 病例。年龄与对照组报告的事件数量呈负相关。

结论

研究者管理的 LTE-Q 为逆境提供了一种适用于大型基因关联研究的病例对照差异的衡量标准。事件报告的混杂因素包括当前情绪和年龄。

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