MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK.
J Affect Disord. 2010 Sep;125(1-3):345-9. doi: 10.1016/j.jad.2010.01.071. Epub 2010 Feb 20.
Gene-environment interactions may contribute to the high heritability of bipolar affective disorder. The aim of the present study was to examine the interplay between the BDNF Val(66)Met polymorphism and stressful life events (SLEs) in bipolar disorder.
A total of 1085 participants were recruited, including 487 bipolar I cases and 598 psychiatrically healthy controls. All participants completed the List of Threatening Life Events Questionnaire; bipolar subjects reported the events that occurred 6 months leading up to their worst manic episode and 6 months prior to their worst depressive episode, controls recorded events experienced 6 months before interview. The sample was genotyped for the BDNF Val(66)Met polymorphism (rs6265).
Both Met carrier BDNF genotype and SLEs were significantly associated with the worst depressive episode of bipolar disorder. For the worst depressive episodes the effects of SLEs were also significantly moderated by BDNF genotype (gene x environment interaction).
The use of a self report questionnaire to measure stressful life events may increase recall inaccuracies, therefore caution should be taken when interpreting these results.
The findings of this study highlight the importance of the interplay between genes and the environment in bipolar disorder.
基因-环境相互作用可能导致双相情感障碍的高遗传性。本研究旨在探讨 BDNF Val(66)Met 多态性与双相情感障碍中的应激性生活事件（SLEs）之间的相互作用。
共招募了 1085 名参与者，包括 487 名双相 I 型病例和 598 名精神健康对照者。所有参与者均完成了威胁生命事件清单问卷；双相患者报告了发生在他们最严重躁狂发作前 6 个月和最严重抑郁发作前 6 个月的事件，对照者记录了在访谈前 6 个月经历的事件。对 BDNF Val(66)Met 多态性(rs6265)进行了基因分型。
Met 携带者 BDNF 基因型和 SLEs 均与双相情感障碍的最严重抑郁发作显著相关。对于最严重的抑郁发作，SLEs 的影响也显著受到 BDNF 基因型的调节（基因 x 环境相互作用）。
使用自我报告问卷来测量应激性生活事件可能会增加回忆不准确，因此在解释这些结果时应谨慎。
本研究的结果强调了基因和环境在双相情感障碍中的相互作用的重要性。
