Zhao Mingzhe, Yang Jiarun, Qiu Xiaohui, Yang Xiuxian, Qiao Zhengxue, Song Xuejia, Wang Lin, Zhao Erying, Yang Yanjie, Cao Depin
Psychology Department of the Public Health Institute of Harbin Medical University, Harbin, China.
Department of Health Management of Harbin Medical University, Harbin, China.
Front Psychiatry. 2020 Jan 22;10:982. doi: 10.3389/fpsyt.2019.00982. eCollection 2019.
is a novel variant in discovery of replicable associations in major depressive disorder (MDD). However, there have been no specific studies considered effect of environmental pathogens to date examining its clinical significance. In this study we investigated the interaction effect between polymorphism and threatening life events (TLEs) in MDD and carried out a meta-analysis of published findings.
A total of 1,177 consecutive participants were genotyped. Information on exposure to TLEs, socio-demographic data, and history of psychological problems among first-degree relatives was collected. MDD was diagnosed according to the Chinese version of the 24-item Hamilton Rating Scale for Depression.
There was a significant interaction effect between polymorphism and TLEs in MDD. A dose-response relationship was found between genotypes and TLEs in MDD. The results of the meta-analysis showed that genotypes interacted with TLEs in MDD.
genotype and previous exposure to TLEs interact to influence the risk of developing MDD. We propose that may represent a target for novel pharmacological therapies to prevent or treat MDD.
[具体基因或因素]是在重度抑郁症（MDD）中发现可重复关联的一种新型变异。然而，迄今为止尚无专门研究考虑环境病原体的影响并检验其临床意义。在本研究中，我们调查了MDD中[具体基因或因素]多态性与威胁生命事件（TLEs）之间的相互作用，并对已发表的研究结果进行了荟萃分析。
对总共1177名连续参与者进行基因分型。收集了关于接触TLEs、社会人口统计学数据以及一级亲属心理问题史的信息。根据中文版24项汉密尔顿抑郁量表诊断MDD。
MDD中[具体基因或因素]多态性与TLEs之间存在显著的相互作用。在MDD中发现[具体基因或因素]基因型与TLEs之间存在剂量反应关系。荟萃分析结果表明，MDD中[具体基因或因素]基因型与TLEs相互作用。
[具体基因或因素]基因型与既往接触TLEs相互作用，影响患MDD的风险。我们提出，[具体基因或因素]可能代表预防或治疗MDD的新型药物疗法的一个靶点。
