Laboratory of Regulation in Metabolism and Behavior, Graduate School of Bioresources and Bioenvironmental Sciences, Kyushu University, Fukuoka, Japan.
Nutr Neurosci. 2010 Feb;13(1):17-20. doi: 10.1179/147683010X12611460763481.
To clarify whether L-ornithine and/or its metabolite involves sedative and hypnotic effects under social separation stress, the effects of intracerebroventricular (i.c.v.) injection of L-ornithine and polyamines (putrescine, spermidine and spermine) were compared in chicks. Birds were injected i.c.v. with 0.5 mumol of L-ornithine, putrescine, spermidine, spermine or saline (control). After injection, chicks were immediately separated from the flock and monitored for the number of distress vocalizations and various postures. L-Ornithine greatly attenuated the stress response and caused sedative and hypnotic effects. Among the polyamines, only putrescine attenuated distress vocalizations but did not induce sleep. In conclusion, the sedative and hypnotic effect of L-ornithine was mainly induced by L-ornithine itself, while the polyamines contributed to the sedative, but not hypnotic, effect under social separation stress.
为了阐明 L-鸟氨酸及其代谢物是否在社交分离应激下具有镇静和催眠作用，比较了脑室（i.c.v.）内注射 L-鸟氨酸和多胺（腐胺、精胺和精脒）对雏鸡的影响。鸟类脑室注射 0.5µmol 的 L-鸟氨酸、腐胺、精胺、精脒或生理盐水（对照）。注射后，雏鸡立即与鸡群分离，并监测其发出的痛苦叫声和各种姿势的数量。L-鸟氨酸大大减弱了应激反应，并产生镇静和催眠作用。在多胺中，只有腐胺减弱了痛苦叫声，但没有诱导睡眠。总之，L-鸟氨酸的镇静和催眠作用主要是由 L-鸟氨酸本身引起的，而多胺在社交分离应激下有助于镇静，但不催眠。
