研究 TNFalpha-308G/A 和 IL6-174G/C 多态性在突尼斯人群 2 型糖尿病和肥胖风险中的作用。
Study of TNFalpha -308G/A and IL6 -174G/C polymorphisms in type 2 diabetes and obesity risk in the Tunisian population.
机构信息
Laboratory of Genetics, Immunology and Human Pathologies, Faculty of Sciences of Tunis, 2092 Tunis, Tunisia.
出版信息
Clin Biochem. 2010 Apr;43(6):549-52. doi: 10.1016/j.clinbiochem.2010.01.008. Epub 2010 Feb 2.
OBJECTIVES
We investigated two genetic markers in pro inflammatory molecules : TNFalpha -308G/A and IL6 -174G/C in order to assess their effect on type 2 diabetes (T2D) and obesity in the Tunisian population.
DESIGN AND METHODS
The study sample includes 228 patients with T2D and 300 healthy controls. Genotyping of IL6 -174G/C (rs1800795) was performed using Automated Dye Terminator Sequencing and of TNFalpha -308G/A (rs1800629) using the LightTyper technology.
RESULTS
SNPs IL6 -174G/C and TNFalpha -308G/A are associated neither with T2D (p=0.89, p=0.34 respectively) nor with risk for overweight (p=0.86, p=0.12 respectively) in Tunisian population. Bonferroni correction showed that the founded association of IL6 -174G/C SNP with T2D susceptibility restricted to overweight patients (p(nominal)=0.03, p(corrected)=0.0033) is likely to be a random result.
CONCLUSION
SNPs IL6 -174G/C and TNFalpha -308G/A are not major contributors to T2D or obesity risk in our Tunisian population.
目的
我们研究了两种促炎分子中的遗传标记：TNFalpha -308G/A 和 IL6 -174G/C，以评估它们对 2 型糖尿病（T2D）和肥胖在突尼斯人群中的影响。
设计和方法
研究样本包括 228 例 T2D 患者和 300 名健康对照者。采用自动染料终止测序法检测 IL6 -174G/C(rs1800795)的基因分型，采用 LightTyper 技术检测 TNFalpha -308G/A(rs1800629)的基因分型。
结果
IL6 -174G/C 和 TNFalpha -308G/A 单核苷酸多态性与 T2D（p=0.89，p=0.34）或超重（p=0.86，p=0.12）均无相关性。Bonferroni 校正显示，IL6 -174G/C 单核苷酸多态性与 T2D 易感性的相关性仅限于超重患者（p（名义）=0.03，p（校正）=0.0033），这可能是一个随机结果。
结论
在我们的突尼斯人群中，IL6 -174G/C 和 TNFalpha -308G/A 单核苷酸多态性不是 T2D 或肥胖风险的主要因素。
Zotero 插件