Cheng Zhiying, Zhang Chunmin, Mi Yuanyuan
General Practice, DeltaHealth Hospital, Shanghai, China.
Xinqiao Town Community Health Service Center, Songjiang District, Shanghai, China.
Diabetol Metab Syndr. 2022 Jul 15;14(1):95. doi: 10.1186/s13098-022-00851-8.
Over the past two decades, several studies have focused on the association between a common polymorphism (rs1800795) from interleukin-6 (IL-6) gene and Diabetes Mellitus (DM) risk. However, the results remain ambiguous and indefinite.
A comprehensive analysis was performed to explore this relationship. A search was conducted in the PubMed, Embase, Chinese (CNKI and Wanfang), and GWAS Catalog databases, covering all publications until February 10, 2022. Odds ratios (OR) with 95% confidence intervals (CI) were used to evaluate the strength of the association. Publication bias was assessed using both Begg and Egger tests.
Overall, 34 case-control studies with 7257 T2DM patients and 15,598 controls, and 12 case-control studies (10,264 T1DM patients and 9031 health controls) were included in the analysis. A significantly lower association was observed between the rs1800795 polymorphism and T2DM risk in Asians, mixed population, and hospital-based (HB) subgroups (C-allele vs. G-allele: OR = 0.76, 95% CI 0.58-0.99, P = 0.039 for Asians; CG vs. GG: OR = 0.74, 95% CI 0.58-0.94, P = 0.014 for mixed population; CC vs. GG: OR = 0.61, 95% CI 0.41-0.90, P = 0.014 for HB). However, increased associations were found from total, mixed population, and HB subgroups between rs1800795 polymorphism and T1DM susceptibility (CG vs. GG: OR = 1.32, 95% CI 1.01-1.74, P = 0.043 for total population, CC vs. GG: OR = 2.45, 95% CI 1.18-5.07, P = 0.016 for mixed individuals; C-allele vs. G-allele: OR = 1.29, 95% CI 1.07-1.56, P = 0.0009 for HB subgroup).
In summary, there is definite evidence to confirm that IL-6 rs1800795 polymorphism is associated with susceptibility to decreased T2DM and increased T1DM.
在过去二十年中，多项研究聚焦于白细胞介素-6（IL-6）基因的一种常见多态性（rs1800795）与糖尿病（DM）风险之间的关联。然而，结果仍不明确且不确定。
进行了一项综合分析以探究这种关系。在PubMed、Embase、中文数据库（中国知网和万方）以及全基因组关联研究（GWAS）目录数据库中进行检索，涵盖截至2022年2月10日的所有出版物。采用优势比（OR）及95%置信区间（CI）来评估关联强度。使用Begg检验和Egger检验评估发表偏倚。
总体而言，分析纳入了34项病例对照研究（7257例2型糖尿病患者和15598例对照）以及12项病例对照研究（10264例1型糖尿病患者和9031例健康对照）。在亚洲人、混合人群以及基于医院的（HB）亚组中，观察到rs1800795多态性与2型糖尿病风险之间存在显著较低的关联（C等位基因与G等位基因：亚洲人OR = 0.76，95% CI 0.58 - 0.99，P = 0.039；CG与GG：混合人群OR = 0.74，95% CI 0.58 - 0.94，P = 0.014；CC与GG：HB亚组OR = 0.61，95% CI 0.41 - 0.90，P = 0.014）。然而，在总体、混合人群以及HB亚组中发现rs1800795多态性与1型糖尿病易感性之间存在增加的关联（CG与GG：总体人群OR = 1.32，95% CI 1.01 - 1.74，P = 0.043；CC与GG：混合个体OR = 2.45，95% CI 1.18 - 5.07，P = 0.016；C等位基因与G等位基因：HB亚组OR = 1.29，95% CI 1.07 - 1.56，P = 0.0009）。
总之，有确凿证据证实IL-6 rs1800795多态性与2型糖尿病易感性降低以及1型糖尿病易感性增加相关。
