Genetics of Complex Diseases Laboratory, Federal University of Pará, Belém, Brazil; Programa de Pós-Graduação em Biologia de Agentes Infecciosos e Parasitários, Belém, Brazil.
Institute of Integrative Biology, University of Liverpool, Liverpool, UK; Center for Biomedical Research, Faculty of Medicine, Autonomous University of Coahuila, Torreon, Mexico.
Hum Immunol. 2021 Apr;82(4):247-254. doi: 10.1016/j.humimm.2021.01.008. Epub 2021 Jan 20.
Immunorelevant genes are among the most probable modulators of coronavirus disease 2019 (COVID-19) progression and prognosis. However, in the few months of the pandemic, data generated on host genetics has been scarce. The present study retrieved data sets of HLA-B alleles, KIR genes and functional single nucleotide polymorphisms (SNPs) in cytokines related to COVID-19 cytokine storm from two publicly available databases: Allele Frequency Net Database and Ensembl, and correlated these frequency data with Case Fatality Rate (CFR) and Daily Death Rates (DDR) across countries. Correlations of eight HLA-B alleles and polymorphisms in three cytokine genes (IL6, IL10, and IL12B) were observed and were mainly associated with DDR. Additionally, HLA-B correlations suggest that differences in allele affinities to SARS-CoV-2 peptides are also associated with DDR. These results may provide rationale for future host genetic marker surveys on COVID-19.
免疫相关基因是 2019 年冠状病毒病（COVID-19）进展和预后的最可能的调节剂之一。然而，在大流行的短短几个月内，有关宿主遗传学的数据就很少。本研究从两个公开可用的数据库：Allele Frequency Net Database 和 Ensembl 中检索了与 COVID-19 细胞因子风暴相关的 HLA-B 等位基因、KIR 基因和细胞因子功能单核苷酸多态性（SNP）的数据，并将这些频率数据与各国的病死率（CFR）和日死亡率（DDR）相关联。观察到八个 HLA-B 等位基因和三个细胞因子基因（IL6、IL10 和 IL12B）中的多态性的相关性，并且主要与 DDR 相关。此外，HLA-B 的相关性表明，SARS-CoV-2 肽的等位基因亲和力的差异也与 DDR 相关。这些结果可能为 COVID-19 的未来宿主遗传标记调查提供依据。
