The State Key Laboratory of Oral Diseases, Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chendgu, China.
Biomaterials. 2010 Apr;31(12):3266-73. doi: 10.1016/j.biomaterials.2010.01.028. Epub 2010 Feb 4.
This study aimed to investigate the effects of hydrofluoric acid (HF) treatment of grit-blasted Ti implants on osseointegration in ovariectomized (OVX) rats. After blasting with aluminium oxide particles, half implants were treated with 0.2 vol.% HF, and the other half were kept non-modified as control. The topographical and chemical changes of implant surface were determined by Scanning Electron Microscope, Atomic Force Microscope, and X-ray Photoemission Spectroscopy. 12 Weeks after bilateral ovariectomy, each rat accepted two implants in distal femora, with the control implant on the left and the fluoride-modified on the right. As a result, fluoride modification induced markedly changed surface topography and chemical composition. 12 Weeks after implant insertion, the fluoride-modified implants showed improved osseointegration compared to control, with the bone area ratio and bone-to-implant contact increased by 0.9- and 1.4-fold in histomorphometry, the bone volume ratio and percent osseointegration by 0.8- and 1.3-fold in micro-CT evaluation, and the maximal push-out force and ultimate shear strength by 1.2- and 2.0-fold in biomechanical test. These promising results indicated that HF treatment of Ti surface improved implant osseointegration in OVX rats, and suggested the feasibility of using fluoride modification to improve Ti implant osseointegration in osteoporotic bone.
本研究旨在探讨酸蚀处理对喷砂钛种植体在去卵巢大鼠中骨整合的影响。经过氧化铝颗粒喷砂处理后，一半的种植体用 0.2vol.%氢氟酸处理，另一半保持未修饰作为对照。通过扫描电子显微镜、原子力显微镜和 X 射线光电子能谱分析，确定了种植体表面形貌和化学变化。双侧卵巢切除 12 周后，每只大鼠接受了两个种植体，分别植入在股骨远端，左侧为对照种植体，右侧为氟改性种植体。结果表明，氟改性诱导了明显改变的表面形貌和化学组成。种植体插入 12 周后，氟改性种植体与对照组相比，表现出更好的骨整合，组织形态计量学中骨面积比和骨-种植体接触增加了 0.9-和 1.4 倍，微 CT 评估中骨体积比和骨整合百分比增加了 0.8-和 1.3 倍，生物力学测试中最大推出力和最终剪切强度增加了 1.2-和 2.0 倍。这些有前景的结果表明，酸蚀处理可改善钛种植体在去卵巢大鼠中的骨整合，提示氟改性可能用于改善骨质疏松性骨中的钛种植体骨整合。
