Langham M E, Grebe R, Hopkins S, Marcus S, Sebag M
Ocular Pharmacology and Therapeutics Unit, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Exp Eye Res. 1991 Feb;52(2):167-73. doi: 10.1016/0014-4835(91)90256-e.
The ocular hemodynamics in diabetic patients with increasingly severe retinopathy have been evaluated using a non-invasive computerized methodology. In a group of 19 healthy volunteers the mean ophthalmic arterial pressure and the ocular pulsatile blood flow were 83 +/- 2.4 mmHg and 648 +/- 42 microliters min-1 respectively. Nine diabetics with no apparent retinopathy had ophthalmic pressures and pulsatile blood flows similar to those in the control subjects. In 11 diabetic patients with background retinopathy the mean pulsatile blood flow was 471 +/- 70 microliters min-1. Thirteen diabetics with proliferative retinopathy had a pulsatile blood flow of 210 +/- 37 microliters min-1 and abnormally low ophthalmic arterial pressures. The results provide evidence that the choroidal blood flow decreases with the severity of the retinopathy in diabetes due to increased vascular resistance and a decreased ocular perfusion pressure.
已使用非侵入性计算机方法对患有日益严重视网膜病变的糖尿病患者的眼部血流动力学进行了评估。在一组19名健康志愿者中，平均眼动脉压和眼部搏动性血流分别为83±2.4 mmHg和648±42微升/分钟。9名无明显视网膜病变的糖尿病患者的眼内压和搏动性血流与对照组相似。11名患有背景性视网膜病变的糖尿病患者的平均搏动性血流为471±70微升/分钟。13名患有增殖性视网膜病变的糖尿病患者的搏动性血流为210±37微升/分钟，且眼动脉压异常低。结果表明，由于血管阻力增加和眼灌注压降低，糖尿病视网膜病变严重程度增加时脉络膜血流减少。
