MacKinnon J R, O'Brien C, Swa K, Aspinall P, Butt Z, Cameron D
Princess Alexandra Eye Pavilion, Edinburgh, Scotland.
Acta Ophthalmol Scand. 1997 Dec;75(6):661-4. doi: 10.1111/j.1600-0420.1997.tb00626.x.
To measure the pulsatile component of total ocular blood flow in patients with untreated diabetic retinopathy.
An adapted pneumotonometer attached to a slit-lamp biomicroscope. 82 age-matched subjects divided into 4 groups: non-diabetic controls (n = 22); diabetics with no clinical retinopathy (n = 20); background diabetic retinopathy (n = 20); pre-proliferative/proliferative diabetic retinopathy (n = 20).
The mean pulsatile ocular blood flow values were found to be increased in all grades of diabetic retinopathy (no retinopathy 818 microl/min, background 1015 microl/min, pre-proliferative/proliferative 1097 microl/min) compared to the control group (644 microl/min). These pulsatile ocular blood flow values were significantly higher (p<0.05) in the background and pre-proliferative/proliferative retinopathy groups compared to controls. Pulse volume and pulse amplitude were also higher in the diabetic subjects. Mean arterial blood pressure did not differ across the groups studied.
Pulsatile ocular blood flow was found to be higher in diabetics compared to controls and appears to increase as the severity of retinopathy progresses. Such a hyperdynamic circulation may contribute to the pathogenesis of diabetic eye disease.
测量未经治疗的糖尿病视网膜病变患者全眼血流的搏动成分。
将改良的眼压计连接到裂隙灯生物显微镜上。82名年龄匹配的受试者分为4组：非糖尿病对照组（n = 22）；无临床视网膜病变的糖尿病患者（n = 20）；背景性糖尿病视网膜病变患者（n = 20）；增殖前期/增殖性糖尿病视网膜病变患者（n = 20）。
与对照组（644微升/分钟）相比，所有等级的糖尿病视网膜病变患者（无视网膜病变818微升/分钟，背景性1015微升/分钟，增殖前期/增殖性1097微升/分钟）的平均搏动性眼血流值均升高。与对照组相比，背景性和增殖前期/增殖性视网膜病变组的这些搏动性眼血流值显著更高（p<0.05）。糖尿病受试者的脉量和脉幅也更高。研究的各组之间平均动脉血压无差异。
与对照组相比，糖尿病患者的搏动性眼血流更高，并且似乎随着视网膜病变严重程度的进展而增加。这种高动力循环可能有助于糖尿病眼病的发病机制。
