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在成人和儿童囊性纤维化患者中,测量肾功能的最佳方法是什么?

What is the best method for measuring renal function in adults and children with cystic fibrosis?

机构信息

Sansom Institute, University of South Australia, Frome Road, Adelaide, SA 5001, Australia.

出版信息

J Cyst Fibros. 2010 Mar;9(2):124-9. doi: 10.1016/j.jcf.2009.12.002. Epub 2010 Feb 4.

DOI:10.1016/j.jcf.2009.12.002
PMID:20133211
Abstract

To measure the glomerular filtration rate (GFR) in adults and children with cystic fibrosis (CF) using a radio-isotope technique as the gold standard and to compare this to serum creatinine based equations, serum cystatin C levels and tobramycin clearance, and to determine which method correlates most closely with measured GFR in this population.

摘要

采用放射性同位素技术测量成人和儿童囊性纤维化(CF)患者的肾小球滤过率(GFR),并将其与基于血清肌酐的公式、血清胱抑素 C 水平和妥布霉素清除率进行比较,以确定哪种方法与该人群的实测 GFR 相关性最高。

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What is the best method for measuring renal function in adults and children with cystic fibrosis?在成人和儿童囊性纤维化患者中,测量肾功能的最佳方法是什么?
J Cyst Fibros. 2010 Mar;9(2):124-9. doi: 10.1016/j.jcf.2009.12.002. Epub 2010 Feb 4.
2
Performance of the creatinine-based and the cystatin C-based glomerular filtration rate (GFR) estimating equations in a heterogenous sample of patients referred for nuclear GFR testing.在接受核 GFR 检测的患者的异质样本中,基于肌酐和胱抑素 C 的肾小球滤过率(GFR)估算方程的性能。
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Serum cystatin C level for better assessment of glomerular filtration rate in cystic fibrosis patients treated by amikacin.血清胱抑素C水平用于更好地评估接受阿米卡星治疗的囊性纤维化患者的肾小球滤过率。
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[Comparison of four methods for measuring glomerular filtration rate by inulin clearance in healthy individuals and patients with renal failure].[健康个体及肾衰竭患者中通过菊粉清除率测量肾小球滤过率的四种方法的比较]
Nefrologia. 2010;30(3):324-30. doi: 10.3265/Nefrologia.pre2010.Mar.10238. Epub 2010 Mar 23.
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Prediction of glomerular filtration rate from serum concentration of cystatin C: comparison of two analytical methods.基于血清胱抑素 C 浓度预测肾小球滤过率:两种分析方法的比较。
Nephrol Dial Transplant. 2012 Jul;27(7):2826-38. doi: 10.1093/ndt/gfs010. Epub 2012 Mar 15.
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The effects of intravenous tobramycin on renal tubular function in children with cystic fibrosis.静脉注射妥布霉素对囊性纤维化患儿肾小管功能的影响。
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GFR estimates using cystatin C are superior to serum creatinine in adult patients with cystic fibrosis.在成年囊性纤维化患者中,使用胱抑素C估算的肾小球滤过率(GFR)优于血清肌酐。
J Cyst Fibros. 2009 Jan;8(1):19-25. doi: 10.1016/j.jcf.2008.07.004. Epub 2008 Sep 16.
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Serum cystatin C for the prediction of glomerular filtration rate with regard to the dose adjustment of amikacin, gentamicin, tobramycin, and vancomycin.血清胱抑素C用于在调整阿米卡星、庆大霉素、妥布霉素和万古霉素剂量时预测肾小球滤过率。
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Measuring glomerular filtration rate with cystatin C and beta-trace protein in children with spina bifida.利用胱抑素C和β-微量蛋白测量脊柱裂患儿的肾小球滤过率。
J Urol. 2003 Jun;169(6):2312-5. doi: 10.1097/01.ju.0000060205.23406.13.
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The Lund-Malmö creatinine-based glomerular filtration rate prediction equation for adults also performs well in children.基于肌酐的成人Lund-Malmö肾小球滤过率预测方程在儿童中也表现良好。
Scand J Clin Lab Invest. 2008;68(7):568-76. doi: 10.1080/00365510801915163.

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Front Transplant. 2022 Sep 23;1:992985. doi: 10.3389/frtra.2022.992985. eCollection 2022.
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CPT Pharmacometrics Syst Pharmacol. 2022 Aug;11(8):951-966. doi: 10.1002/psp4.12832. Epub 2022 Jun 29.
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Estimation of GFR in Patients With Cystic Fibrosis: A Cross-Sectional Study.
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Clin Pharmacokinet. 2019 Oct;58(10):1323-1332. doi: 10.1007/s40262-019-00761-5.
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Evaluation of bone disease in patients with cystic fibrosis and end-stage lung disease.囊性纤维化和终末期肺病患者的骨病评估
J Bras Pneumol. 2019 Feb 28;45(1):e20170280. doi: 10.1590/1806-3713/e20170280.
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Urinary Biomarkers of Aminoglycoside-Induced Nephrotoxicity in Cystic Fibrosis: Kidney Injury Molecule-1 and Neutrophil Gelatinase-Associated Lipocalin.囊性纤维化中氨基糖苷类诱导的肾毒性的尿生物标志物:肾损伤分子 1 和中性粒细胞明胶酶相关脂质运载蛋白。
Sci Rep. 2018 Mar 23;8(1):5094. doi: 10.1038/s41598-018-23466-4.
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Urinary kidney injury biomarkers and tobramycin clearance among children and young adults with cystic fibrosis: a population pharmacokinetic analysis.囊性纤维化儿童和青年中尿肾损伤生物标志物与妥布霉素清除率:一项群体药代动力学分析
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