Nattie Eugene, Li Aihua
Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756-0001, USA.
J Appl Physiol (1985). 2010 May;108(5):1417-24. doi: 10.1152/japplphysiol.01261.2009. Epub 2010 Feb 4.
This minireview examines data showing the locations of central chemoreceptor sites as identified by the presence of ventilatory responses to focal, mild acidification produced in unanesthetized animals in vivo, how the site-specific responses vary by arousal state, and what the emerging role of orexin might be in this state-dependent central chemoreceptor system. We comment on the organization of this distributed central chemoreceptor system and suggest that interactions among sites are synergistic and not additive, which is an important aspect of its normal function.
本综述考察了相关数据，这些数据表明了在未麻醉动物体内通过对局部轻度酸化产生的通气反应所确定的中枢化学感受器位点的位置、位点特异性反应如何随觉醒状态而变化，以及食欲素在这种状态依赖性中枢化学感受器系统中可能出现的作用。我们对这个分布式中枢化学感受器系统的组织进行了评论，并指出位点之间的相互作用是协同的而非累加的，这是其正常功能的一个重要方面。
