Department of Physiology, Auckland Bioengineering Institute, The University of Auckland, Private Bag 92019, Auckland, New Zealand.
J Appl Physiol (1985). 2010 Jun;108(6):1465-71. doi: 10.1152/japplphysiol.01198.2009. Epub 2010 Feb 4.
We trace the history of attempts to determine whether the experimentally observed diminution of metabolic energy expenditure when muscles lengthen during active contraction is consistent with reversibility of biochemical reactions and, in particular, with the regeneration of ATP. We note that this scientific endeavor has something of a parallel flavor to it, with both early and more recent experiments exploiting both isolated muscle preparations and exercising human subjects. In tracing this history from the late 19th century to the present, it becomes clear that energy can be (at least transiently) stored in a muscle undergoing an eccentric contraction but that this is unlikely to be due to the regeneration of ATP. A recently developed, thermodynamically constrained model of the cross-bridge cycle provides additional insight into this conclusion.
我们追溯了尝试确定在肌肉主动收缩时伸展过程中代谢能量消耗减少的实验观察结果是否与生化反应的可逆性，特别是与 ATP 再生相一致的历史。我们注意到，这项科学研究具有一定的相似性，早期和近期的实验都利用了分离的肌肉标本和进行运动的人体受试者。从 19 世纪末到现在，随着历史的追溯，我们清楚地了解到，能量可以（至少是暂时地）储存在进行离心收缩的肌肉中，但这不太可能是由于 ATP 的再生。最近开发的，受到热力学约束的横桥循环模型为这一结论提供了更多的见解。
