Berardesca E, Farinelli N, Rabbiosi G, Maibach H I
Department of Dermatology, University of Pavia, IRCCS Policlinico S. Matteo, Italy.
Dermatologica. 1991;182(1):1-6. doi: 10.1159/000247727.
Cutaneous changes induced by aging can be quantified and monitored noninvasively by means of bioengineering tools. Skin elasticity, hydration, skin blood flow and skin surface pattern show age-related changes reflecting the damage of cutaneous structures involved. Impairment and degeneration of elastic and collagen networks are responsible for the progressive decrease in skin elasticity recorded during aging. Reduction in blood flow and water supply with probably defective stratum corneum binding result in reduced stratum corneum water content and transepidermal water loss. Morphological changes such as increased skin roughness, pigmentation and alteration of skin surface pattern appearing from the age of 30 years onwards may be investigated at a subclinical level allowing the detection of early signs of aging.
衰老引起的皮肤变化可以通过生物工程工具进行无创量化和监测。皮肤弹性、水合作用、皮肤血流量和皮肤表面形态呈现出与年龄相关的变化，反映了所涉及的皮肤结构的损伤。弹性和胶原网络的损伤与退化是衰老过程中皮肤弹性逐渐下降的原因。血流量和水分供应减少，可能伴有角质层结合缺陷，导致角质层含水量降低和经表皮水分流失。从30岁起出现的皮肤粗糙度增加、色素沉着和皮肤表面形态改变等形态学变化，可以在亚临床水平进行研究，从而检测出衰老的早期迹象。
