Wilhelm K P, Cua A B, Maibach H I
Department of Dermatology, University of California-San Francisco, School of Medicine 94143-0989.
Arch Dermatol. 1991 Dec;127(12):1806-9. doi: 10.1001/archderm.127.12.1806.
This study investigates the effect of cutaneous aging on transepidermal water loss, stratum corneum hydration (capacitance), skin surface pH, and causal sebum content. Because the physiologic condition of skin varies considerably with anatomic region and skin aging might demonstrate regional variability, all factors were studied on 11 anatomic locations in 14 young adult (seven female and seven male subjects; 26.7 +/- 2.8 years [mean +/- SD]) and 15 aged human volunteers (seven female and seven male subjects; 70.5 +/- 13.8 years). Significant anatomic variability was noted for all factors in both age groups. However, no significant differences between the two groups were noted for sebum, capacitance, and pH on most anatomic regions. Transepidermal water loss, however, was significantly lower in the aged population on all anatomic regions tested, except for the postauricular region and the palm. Comparing male and female volunteers, none of the four factors showed significant differences. Of all measured factors, only transepidermal water loss showed significant age-related differences on most anatomic regions studied. The additionally observed differences between the age groups on the ankle for pH and sebum might be related to the stasis frequently observed on the lower limbs in aged individuals.
本研究调查了皮肤老化对经表皮水分流失、角质层水合作用（电容）、皮肤表面pH值和皮脂含量的影响。由于皮肤的生理状况随解剖部位的不同而有很大差异，且皮肤老化可能表现出区域变异性，因此对14名年轻成年人（7名女性和7名男性受试者；26.7±2.8岁[平均值±标准差]）和15名老年志愿者（7名女性和7名男性受试者；70.5±13.8岁）的11个解剖部位的所有因素进行了研究。两个年龄组的所有因素均存在显著的解剖学变异性。然而，在大多数解剖区域，两组之间的皮脂、电容和pH值没有显著差异。然而，除耳后区域和手掌外，所有测试解剖区域的老年人群经表皮水分流失均显著低于年轻人群。比较男性和女性志愿者，这四个因素均未显示出显著差异。在所有测量因素中，只有经表皮水分流失在大多数研究的解剖区域显示出与年龄相关的显著差异。另外观察到的年龄组在脚踝处pH值和皮脂的差异可能与老年人下肢经常出现的淤血有关。
