Berardesca E, Maibach H I
Department of Dermatology, University of California Medical School, San Francisco.
Derm Beruf Umwelt. 1990 Mar-Apr;38(2):50-3.
Transepidermal water loss (TEWL) and water content of the stratum corneum, when measured simultaneously, provide important information regarding skin function. On the basis of the model presented, it is possible to differentiate dry senile skin from dry pathological skin (such as psoriasis, atopic dermatitis, irritant reaction), clinically involved or uninvolved. Pathological dry skin, because of the impaired barrier function is associated with increased TEWL and low corneum water content. Senile skin, on the other hand, shows both, decreased TEWL and stratum corneum water content. It is suggested that with this model it may be possible to differentiate uninvolved pathologic from healthy skin.
经表皮水分流失（TEWL）和角质层含水量同时测量时，可提供有关皮肤功能的重要信息。基于所提出的模型，临床上受累或未受累的干性老年皮肤与干性病理性皮肤（如银屑病、特应性皮炎、刺激性反应）之间有可能进行区分。病理性干性皮肤由于屏障功能受损，其TEWL增加且角质层含水量低。另一方面，老年皮肤的TEWL和角质层含水量均降低。有人提出，利用该模型可能区分未受累的病理性皮肤和健康皮肤。
