大脑皮层中铁含量的层特异性变化作为 MRI 对比的来源。
Layer-specific variation of iron content in cerebral cortex as a source of MRI contrast.
机构信息
Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
出版信息
Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3834-9. doi: 10.1073/pnas.0911177107. Epub 2010 Feb 3.
Abstract
Recent advances in high-field MRI have dramatically improved the visualization of human brain anatomy in vivo. Most notably, in cortical gray matter, strong contrast variations have been observed that appear to reflect the local laminar architecture. This contrast has been attributed to subtle variations in the magnetic properties of brain tissue, possibly reflecting varying iron and myelin content. To establish the origin of this contrast, MRI data from postmortem brain samples were compared with electron microscopy and histological staining for iron and myelin. The results show that iron is distributed over laminae in a pattern that is suggestive of each region's myeloarchitecture and forms the dominant source of the observed MRI contrast.
摘要
近年来，高场 MRI 的发展极大地提高了活体人脑解剖结构的可视化程度。值得注意的是，在皮质灰质中，观察到了强烈的对比度变化，这些变化似乎反映了局部的层状结构。这种对比归因于脑组织磁特性的细微变化，可能反映了不同的铁和髓磷脂含量。为了确定这种对比的起源，对死后脑组织样本的 MRI 数据与铁和髓磷脂的电子显微镜和组织学染色进行了比较。结果表明，铁在层状结构中的分布模式提示了每个区域的髓鞘结构，并构成了观察到的 MRI 对比的主要来源。
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