Olsson R, Danielsson A, Järnerot G, Lindström E, Lööf L, Rolny P, Rydén B O, Tysk C, Wallerstedt S
Medical Clinics at Sahlgrenska Sjukhuset, Göteborg, Sweden.
Gastroenterology. 1991 May;100(5 Pt 1):1319-23.
All patients greater than or equal to 16 years old with a diagnosis of ulcerative colitis were identified in five well-defined catchment areas, representing 12.7% of the Swedish population. Exactly 1500 patients were retrieved, giving a point prevalence of 170/10(5) inhabitants. It was possible to obtain liver function test results less than 2 years old in 94% of the patients and to obtain endoscopic retrograde cholangiographic results in 65 of the 72 patients with abnormal serum alkaline phosphatase values. Primary sclerosing cholangitis was diagnosed in 55 of the patients (3.7%). The prevalence of the disease was 5.5% in patients with substantial colitis and 0.5% in patients with distal colitis. There was a marked male predominance in cholangitis patients compared with colitis patients without cholangitis. Ninety-five percent of the patients with cholangitis had substantial colitis, which was more than the 62% of patients without cholangitis who had colitis. Female patients with cholangitis were older than male patients at the time of diagnosis of both cholangitis and colitis, which contrasted to the equal age at diagnosis of colitis in male and female patients without cholangitis.
在五个明确界定的集水区内，确定了所有年龄大于或等于16岁且诊断为溃疡性结肠炎的患者，这些集水区代表了瑞典12.7%的人口。共检索到1500例患者，患病率为每10（5）名居民中有170例。94%的患者能够获得不到2年的肝功能检查结果，72例血清碱性磷酸酶值异常的患者中有65例能够获得内镜逆行胆管造影结果。55例患者（3.7%）被诊断为原发性硬化性胆管炎。重度结肠炎患者的患病率为5.5%，远端结肠炎患者的患病率为0.5%。与无胆管炎的结肠炎患者相比，胆管炎患者中男性明显居多。95%的胆管炎患者患有重度结肠炎，这一比例高于无胆管炎且患有结肠炎的患者中的62%。在胆管炎和结肠炎诊断时，患有胆管炎的女性患者比男性患者年龄大，这与无胆管炎的男性和女性患者在结肠炎诊断时年龄相同形成对比。
