Rasmussen H H, Fallingborg J F, Mortensen P B, Freund L G, Tage-Jensen U, Kruse V, Rasmussen S N
Aalborg Sygehus, medicinsk gastroenterologisk afdeling M.
Ugeskr Laeger. 1994 Jan 10;156(2):179-82.
The aim of the study was to determine the prevalence of primary sclerosing cholangitis (PSC) in a regional population of patients with ulcerative colitis (UC). Three hundred and five patients with UC followed over a 12 year period were examined for elevations of serum alkaline phosphatase (> 280 U/l). Twenty four such patients were found. If no cause of these elevations were found by initial investigations, endoscopic retrograde cholangiography was performed in order to determine whether they had PSC. Eleven patients were found to have PSC (3.6%), of whom five had progressive disease, including two deaths from cholangio-carcinoma, during a six-year observation period. We found no certain relation between the extent, duration or activity of ulcerative colitis and the presence of PSC. Alkaline phosphatases were elevated up to 3.7 times the upper reference level, the aminotransferases were only found to be mildly elevated.
该研究的目的是确定溃疡性结肠炎（UC）区域患者群体中原发性硬化性胆管炎（PSC）的患病率。对305例随访12年的UC患者进行血清碱性磷酸酶升高（>280 U/l）检测。发现24例此类患者。如果初步检查未发现这些升高的原因，则进行内镜逆行胆管造影以确定他们是否患有PSC。发现11例患者患有PSC（3.6%），其中5例病情进展，包括在六年观察期内有2例死于胆管癌。我们未发现溃疡性结肠炎的范围、病程或活动度与PSC的存在之间有明确关系。碱性磷酸酶升高至参考上限的3.7倍，仅发现转氨酶轻度升高。
