Harvard Medical School, Boston, Massachusetts 02115, USA.
Am J Respir Crit Care Med. 2010 Jun 1;181(11):1170-3. doi: 10.1164/rccm.201001-0069PP. Epub 2010 Feb 4.
Recently a series of genome-wide association study manuscripts in asthma and chronic obstructive pulmonary disease have been published. These papers suggest that, in part, asthma and chronic obstructive pulmonary disease have a common genetic origin, and that this common origin is due to polymorphism in genes that are involved with the development of the lung. This Pulmonary Perspective discusses what we are learning from genome-wide association studies, where the field of genetics and genomics is headed, and how this knowledge will ultimately be put to use in clinical medicine.
最近，一系列关于哮喘和慢性阻塞性肺疾病的全基因组关联研究论文已经发表。这些论文表明，哮喘和慢性阻塞性肺疾病在一定程度上具有共同的遗传起源，而这种共同起源是由于参与肺部发育的基因的多态性所致。本《肺部透视》讨论了我们从全基因组关联研究中学到的知识、遗传学和基因组学领域的发展方向，以及这些知识最终将如何在临床医学中得到应用。
