Department of Cardiology, Abant Izzet Baysal University Faculty of Medicine, Bolu, Turkey.
Clin Hemorheol Microcirc. 2010;44(1):35-41. doi: 10.3233/CH-2010-1249.
Markers of platelet activation and haemorrheological indices have been demonstrated to play a role in the pathophysiology of atherosclerosis and cardiovascular events. In this study, we aimed at investigate the association between plasma viscosity and platelet indices in patients undergoing coronary angiography.
Three hundred and eighty four consecutive patients scheduled to undergo coronary angiography were included in the study. Prior to coronary angiography, blood samples were withdrawn to determine routine biochemical markers, blood cell analyses and viscosity measurements. According to the results of coronary angiography, patients were classified either in a subgroup with coronary artery disease (CAD; 1 or more stenoses >50%) or normal coronary arteries (NCA; no stenoses or <50%).
There was a statistically significant correlation between plasma viscosity and mean platelet volume levels in all patients undergoing coronary angiography (r=0.199, p<0.001). Additionally, when correlation analysis was performed within each group, plasma viscosity significantly correlated with MPV both in patients with CAD (r=0.18, p=0.004) and in patients with NCAs (r=0.272, p=0.002). Linear regression analysis revealed that plasma viscosity was positively associated with MPV while platelet number was inversely but significantly associated with MPV.
We have shown for the first time that MPV correlates with plasma viscosity in patients undergoing coronary angiography, suggesting a relation with plasma proteins and activation of circulating platelets or peripheral consumption of platelets. To evaluate this relation further controlled studies also in patients with acute coronary syndromes are warranted.
血小板活化标志物和血液流变学指标已被证明在动脉粥样硬化和心血管事件的病理生理学中发挥作用。在这项研究中，我们旨在研究接受冠状动脉造影的患者血浆粘度与血小板指数之间的关系。
连续纳入 384 例拟行冠状动脉造影的患者。在进行冠状动脉造影之前，采集血样以确定常规生化标志物、血细胞分析和粘度测量。根据冠状动脉造影的结果，患者被分为冠状动脉疾病亚组（CAD；1 个或多个狭窄>50%）或正常冠状动脉亚组（NCA；无狭窄或<50%）。
所有接受冠状动脉造影的患者的血浆粘度与平均血小板体积水平呈显著正相关（r=0.199，p<0.001）。此外，当在每个组内进行相关分析时，CAD 患者（r=0.18，p=0.004）和 NCA 患者（r=0.272，p=0.002）的血浆粘度与 MPV 均显著相关。线性回归分析表明，血浆粘度与 MPV 呈正相关，而血小板计数与 MPV 呈负相关，但具有统计学意义。
我们首次表明，在接受冠状动脉造影的患者中，MPV 与血浆粘度相关，提示与血浆蛋白和循环血小板的活化或血小板的外周消耗有关。为了进一步评估这种关系，还需要在急性冠状动脉综合征患者中进行对照研究。
