血小板指标与高血压患者视网膜分支静脉阻塞的关系。
Relation between platelet indices and branch retinal vein occlusion in hypertensive patients.
机构信息
Department of Ophthalmology, Duzce University Medical Faculty, Duzce, Turkey.
出版信息
Indian J Ophthalmol. 2013 Apr;61(4):160-2. doi: 10.4103/0301-4738.111063.
Abstract
BACKGROUND
Branch retinal vein occlusion (BRVO) is the second most common retinal vascular disease after diabetic retinopathy. To date, the studies were unable to elucidate the mechanism of the thrombosis leading to the entity; particularly the relation between thrombocyte aggregation and retinal vein occlusion is still unclear. Mean platelet volume (MPV) is a determinant of rate of platelet production and activation, both of which are indices of function of platelets. The relation between MPV and BRVO has not been studied before. The aim was to evaluate MPV in BRVO.
MATERIALS AND METHODS
Forty patients were included in the study. Forty six age and sex matched hypertensive volunteers were recruited as the control group.
RESULTS
MPV values were significantly higher in BRVO patients compared with the control subjects (8.01 ± 0.79 vs 7.52 ± 0.32 fL, respectively; P < 0.001).
CONCLUSION
MPV is significantly higher in patients hypertensive BRVO patients and further investigations regarding its potentially use as a prognostic biomarker in patients with BRVO are needed.
摘要
背景
分支视网膜静脉阻塞（BRVO）是仅次于糖尿病性视网膜病变的第二大常见视网膜血管疾病。迄今为止，尚无研究能够阐明导致该疾病的血栓形成机制；特别是血小板聚集与视网膜静脉阻塞之间的关系仍不清楚。平均血小板体积（MPV）是血小板生成和激活速率的决定因素，这两者都是血小板功能的指标。MPV 与 BRVO 之间的关系尚未被研究过。本研究旨在评估 BRVO 中的 MPV。
材料和方法
共纳入 40 名患者。选择 46 名年龄和性别匹配的高血压志愿者作为对照组。
结果
BRVO 患者的 MPV 值明显高于对照组（8.01±0.79 与 7.52±0.32 fL，分别；P＜0.001）。
结论
BRVO 患者的 MPV 值明显升高，需要进一步研究其作为 BRVO 患者预后生物标志物的潜在用途。
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