Department of Microbiology, Molecular Biology, and Biochemistry, University of Idaho, Moscow, ID 83844, USA.
J Microbiol Biotechnol. 2010 Jan;20(1):5-14.
Enterohemorrhagic Escherichia coli O157:H7 is a major food-borne pathogen causing severe disease in humans worldwide. Healthy cattle are a reservoir of E. coli O157:H7 and bovine food products and fresh produce contaminated with bovine waste are the most common sources for disease outbreaks in the United States. E. coli O157:H7 also survives well in the environment. The ability to cause human disease, colonize the bovine gastrointestinal tract, and survive in the environment, requires that E. coli O157:H7 adapt to a wide variety of conditions. Three major virulence factors of E. coli O157:H7 have been identified including Shiga toxins, a pathogenicity island called the locus of enterocyte effacement, and an F-like plasmid, pO157. Among these virulence factors, the role of the pO157 is least understood. This review provides a board overview of E. coli O157:H7 with an emphasis on the pO157.
产肠出血性大肠杆菌 O157:H7 是一种主要的食源性病原体，可导致全球人类发生严重疾病。健康牛是大肠杆菌 O157:H7 的储存宿主，受牛粪便污染的牛源性食品和新鲜农产品是美国疾病暴发的最常见来源。大肠杆菌 O157:H7 在环境中也能很好地存活。能够引起人类疾病、定殖牛胃肠道以及在环境中存活，需要大肠杆菌 O157:H7 适应各种各样的条件。已经鉴定出大肠杆菌 O157:H7 的三种主要毒力因子，包括志贺毒素、一个称为上皮细胞消失部位的致病性岛和一个 F 样质粒 pO157。在这些毒力因子中，pO157 的作用了解最少。本综述提供了大肠杆菌 O157:H7 的广泛概述，重点介绍了 pO157。
