胰腺癌细针穿刺抽吸物中的定量核DNA含量
Quantitative nuclear DNA content in fine needle aspirates of pancreatic cancer.
作者信息
Weger A R, Glaser K S, Schwab G, Oefner D, Bodner E, Auer G U, Mikuz G
机构信息
Department of Pathology, University of Innsbruck, Austria.
出版信息
Gut. 1991 Mar;32(3):325-8. doi: 10.1136/gut.32.3.325.
The quantitative nuclear DNA content of nuclei from fine needle aspirations from 70 patients with pancreatic cancer was measured using an image analyser system. Retrospective analysis of patients indicated that cases with tumour stemlines in the diploid region had the best chance for radical surgery (p less than 0.006) and the best probability of survival (p less than 0.0004). The prognosis for patients with tetraploid stemlines was intermediate and was poorest for patients with no stemlines in the diploid-tetraploid region. From those parameters assessed postoperatively, only the tumour stage added appreciable information on prognosis to the preoperative quantitative DNA content obtainable. Therefore, in patients with pancreatic cancer the quantitative DNA content should be taken into account in planning treatment and assessing prognosis. Furthermore, the quantitative DNA content may have a major role in stratification for further treatment trials.
使用图像分析仪系统测量了70例胰腺癌患者细针穿刺细胞核的定量核DNA含量。对患者的回顾性分析表明，二倍体区域有肿瘤干系的病例进行根治性手术的机会最大（p<0.006），生存概率也最高（p<0.0004）。四倍体干系患者的预后中等，而在二倍体-四倍体区域无干系的患者预后最差。从术后评估的那些参数来看，只有肿瘤分期能为术前可获得的定量DNA含量所提供的预后信息增添有价值的信息。因此，对于胰腺癌患者，在制定治疗方案和评估预后时应考虑定量DNA含量。此外，定量DNA含量在进一步治疗试验的分层中可能起主要作用。
Zotero 插件