Yoshioka K, Youngs D J, Keighley M R
Department of Surgery, Kansai Medical University, Osaka, Japan.
Infection. 1991 Jan-Feb;19(1):25-9. doi: 10.1007/BF01643754.
A prospective randomised study was undertaken in 80 patients to assess the combined regimen of ciprofloxacin with metronidazole against amoxicillin/clavulanic acid with metronidazole as treatment for established intra-abdominal infection. Treatment was for five days. Seventy-eight patients were clinically evaluable (38 patients on ciprofloxacin with metronidazole and 40 patients on amoxicillin/clavulanic acid with metronidazole). The overall clinical success rate in the treatment of intra-abdominal infections was 96% for the ciprofloxacin with metronidazole group, and 90% for the amoxicillin/clavulanic acid with metronidazole group. Over half of all patients were able to change from intravenous to oral antibiotic administration within the study period. One patient receiving ciprofloxacin with metronidazole developed pruritus near the injection site.
对80例患者进行了一项前瞻性随机研究，以评估环丙沙星与甲硝唑联合用药方案对比阿莫西林/克拉维酸与甲硝唑联合用药方案治疗确诊的腹腔内感染的效果。治疗为期五天。78例患者可进行临床评估（38例接受环丙沙星与甲硝唑联合治疗，40例接受阿莫西林/克拉维酸与甲硝唑联合治疗）。环丙沙星与甲硝唑联合治疗组腹腔内感染的总体临床成功率为96%，阿莫西林/克拉维酸与甲硝唑联合治疗组为90%。超过半数的患者在研究期间能够从静脉注射抗生素改为口服抗生素。一名接受环丙沙星与甲硝唑联合治疗的患者在注射部位附近出现瘙痒。
