Department of Paediatric Cardiology, Evelina Children's Hospital, Guy's and St. Thomas' NHS Foundation Trust, Westminster Bridge Road, London, SE1 7EH, UK.
Clin Res Cardiol. 2010 May;99(5):309-14. doi: 10.1007/s00392-010-0120-3. Epub 2010 Feb 5.
A prolongation of the corrected QT interval (QTc) in the routine ECG of otherwise healthy neonates has been suspected to be a risk factor for sudden infant death. None of the studies published so far differentiated between awake and sleeping neonates.
This study was designed to find possible differences of the QTc when neonates were asleep or awake, and to provide guide values for neonatal QTc in 24-h ECGs.
Hundred neonates (51 male, 49 female, age 2-11 days) underwent ambulatory ECG with defined lead positions. The QT interval was measured constantly in three different leads, and the corrected QT interval was calculated using Bazett's formula. We compared the QTc obtained during sleep with the QTc obtained from wake periods.
The heart rate was significantly higher when the neonates were awake, and when awake higher in girls than in boys. While there was no statistically significant difference between the QTc when the babies were awake or asleep in leads 1 and 3, this reached the level of mathematical significance in the most cranio-caudal lead 2.
Changes of the corrected QT interval in neonates seems to be dependent on the lead position of ambulatory ECGs, and could be found only in one lead. Guide values for the sleeping and awake neonate are provided.
在其他方面健康的新生儿的常规心电图中，校正 QT 间期（QTc）延长被怀疑是婴儿猝死的危险因素。到目前为止，发表的研究都没有区分清醒和睡眠的新生儿。
本研究旨在发现新生儿在睡眠和清醒状态时 QTc 可能存在的差异，并为 24 小时心电图中的新生儿 QTc 提供指导值。
100 名新生儿（51 名男性，49 名女性，年龄 2-11 天）接受了带有规定导联位置的动态心电图检查。QT 间期在三个不同导联中持续测量，并用 Bazett 公式计算校正 QT 间期。我们比较了新生儿睡眠时和觉醒时获得的 QTc。
新生儿清醒时心率显著升高，女孩比男孩更高。当新生儿在导联 1 和 3 时处于清醒或睡眠状态时，QTc 没有统计学上的显著差异，但在最颅尾的导联 2 中，这种差异达到了数学意义上的显著水平。
新生儿校正 QT 间期的变化似乎取决于动态心电图的导联位置，而且只能在一个导联中发现。为睡眠和清醒的新生儿提供了指导值。
