Pathology Department, Ege University Medical School, Bornova, Izmir, Turkey.
Arch Gynecol Obstet. 2010 Dec;282(6):671-6. doi: 10.1007/s00404-010-1373-9. Epub 2010 Feb 5.
Sclerosing stromal tumours (SST) of the ovary are rare, benign tumours. SSTs are usually hormone inactive and tend to occur in the second and third decades of life. The most common clinical symptom is menstrual irregularity.
Fourteen women diagnosed with SST of the ovary were included in this study. Tumour samples were collected, embedded in paraffin and stained with haematoxylin and eosin, periodic acid-Schiff (PAS), and PAS with digestion, as well as immunohistochemically for vimentin, smooth muscle actin, desmin, CD 99, inhibin-α and the oestrogen and progesterone receptor.
The age of the patients ranged from 16 to 54 years (mean age 25.2 years). The tumours ranged in size from 6 to 21 cm (mean 10.5 cm). Macroscopically, eight tumours were solid and six were solid and cystic. All SSTs were well circumscribed with pseudolobule formation. Spindle-shaped fibroblast-like cells and vacuolated theca-like cells were prominent. Blood vessels exhibited a hemangiopericytomatous pattern and boomerang-like features. Immunohistochemical results were as follows: vimentin, 14/14 cases positive; smooth muscle actin, 14/14 cases positive; desmin, 14/14 cases positive; CD 99, 4/14 cases positive; inhibin-α, 14/14 cases positive; oestrogen receptor, 0/14 cases positive; progesterone receptor, 2/14 cases positive.
The characteristic histopathological features we observed in our study are usually adequate for the diagnosis of SSTs. Although inhibin-α, CD 99 and desmin staining may be a useful and reliable tool for SST diagnosis in problematic cases, an immunohistochemical panel will not discriminate from other tumours in the sex cord-stromal group.
卵巢硬化性间质瘤（SST）是一种罕见的良性肿瘤。SST 通常无激素活性，倾向于发生在二十至三十多岁。最常见的临床症状是月经不规则。
本研究纳入了 14 名经诊断患有卵巢 SST 的女性。收集肿瘤样本，石蜡包埋并进行苏木精和伊红染色、过碘酸希夫（PAS）染色、PAS 消化染色以及免疫组织化学染色，检测波形蛋白、平滑肌肌动蛋白、结蛋白、CD99、抑制素-α 以及雌激素和孕激素受体。
患者年龄 16-54 岁（平均 25.2 岁）。肿瘤大小 6-21cm（平均 10.5cm）。大体上，8 个肿瘤为实性，6 个为实性伴囊性。所有 SST 均边界清楚，形成假小叶。梭形成纤维细胞样细胞和空泡状的支持细胞样细胞突出。血管呈血管外皮细胞瘤样和呈弓状特征。免疫组织化学结果如下：波形蛋白，14/14 例阳性；平滑肌肌动蛋白，14/14 例阳性；结蛋白，14/14 例阳性；CD99，4/14 例阳性；抑制素-α，14/14 例阳性；雌激素受体，14/14 例阴性；孕激素受体，2/14 例阳性。
我们在研究中观察到的特征性组织病理学特征通常足以诊断 SST。虽然抑制素-α、CD99 和结蛋白染色可能是诊断疑难病例 SST 的有用且可靠的工具，但免疫组化面板不能将其与性索间质肿瘤组中的其他肿瘤区分开来。
