Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico C. Besta, Milan, Italy.
Neurol Sci. 2010 Apr;31(2):183-8. doi: 10.1007/s10072-010-0217-5. Epub 2010 Feb 5.
Two patients with uncontrollable aggressive behaviour underwent the placement of stimulating leads in the posterior hypothalamus (pHyp). One patient had also multifocal refractory epilepsy. Microrecordings were obtained in both patients during surgery under general anaesthesia. Firing rate, interspike intervals and oscillatory discharge patterns were analysed in 14 neurons. A mean discharge rate of 19 Hz, and oscillatory activity at 7-8 Hz were recorded in the first patient with aggressiveness and epilepsy. In the second patient the mean firing rate was 10 Hz, with evidence of both tonic and random firing patterns. Previous studies in patients with cluster headache showed that a discharge rate around 20 Hz and lack of a specific rhythmic pattern were the most consistent characteristics of neuronal discharge in this area. Our present findings therefore would suggest that the pattern of discharge of neurons in the pHyp should be evaluated with reference to the presence of concurrent pathology.
两名具有不可控攻击性行为的患者在后下丘脑（pHyp）中植入了刺激导联。其中一名患者还患有多灶性耐药性癫痫。两名患者均在全身麻醉下接受手术时进行了微记录。在 14 个神经元中分析了放电率、峰间间隔和振荡放电模式。在有攻击性和癫痫的第一例患者中记录到平均放电率为 19 Hz，并且存在 7-8 Hz 的振荡活动。在第二例患者中，平均放电率为 10 Hz，存在紧张性和随机放电模式的证据。先前在丛集性头痛患者中的研究表明，放电率约为 20 Hz 且缺乏特定的节律模式是该区域神经元放电的最一致特征。因此，我们目前的发现表明，应该根据并发疾病的存在来评估 pHyp 中神经元放电的模式。
