Yang Jenn-Ming, Yang Shwu-Huey, Yang Shu-Yu, Yang Evelyn, Huang Wen-Chen, Tzeng Chii-Ruey
Department of Obstetrics and Gynecology, Taipei Medical University, Taipei, Taiwan, Republic of China.
Int Urogynecol J. 2010 Jun;21(6):637-43. doi: 10.1007/s00192-009-1094-4. Epub 2010 Feb 5.
The pathophysiology of stress urinary incontinence (SUI) is multifactorial. The aim of this study was to explore the factor determining the symptom severity of SUI.
One hundred twenty-four women with SUI were retrospectively investigated. Clinical data for analyses included demographics, pelvic organ prolapse quantification, SUI severity using a 4-point Likert scale, ultrasound, 1-h pad tests, and urodynamic studies. Data were analyzed using the Spearman's rho test and Kruskal-Wallis test.
The symptom severity was not correlated with risk factors of SUI or the morphologic manifestations representing urethral support defect, but was significantly correlated with urine loss on 1-h pad test, Valsalva leak point pressure (VLPP) grading, and maximum urethral closure pressure (MUCP). Women with higher SUI severity had greater urine loss on 1-h pad tests, worse VLPP grading, and lower MUCP.
Urethral sphincter function appears to be an important determinant for the symptom severity of SUI.
压力性尿失禁（SUI）的病理生理学是多因素的。本研究的目的是探讨决定SUI症状严重程度的因素。
对124例SUI女性患者进行回顾性研究。用于分析的临床数据包括人口统计学资料、盆腔器官脱垂量化、采用4级李克特量表评估的SUI严重程度、超声检查、1小时尿垫试验及尿动力学研究。采用Spearman秩相关检验和Kruskal-Wallis检验对数据进行分析。
症状严重程度与SUI的危险因素或代表尿道支持缺陷的形态学表现无关，但与1小时尿垫试验的漏尿量、瓦尔萨尔瓦漏尿点压力（VLPP）分级及最大尿道闭合压（MUCP）显著相关。SUI严重程度较高的女性在1小时尿垫试验中的漏尿量更多、VLPP分级更差且MUCP更低。
尿道括约肌功能似乎是SUI症状严重程度的重要决定因素。
