Department of Dermatology, University Clinic of Regensburg, Germany.
J Dtsch Dermatol Ges. 2010 Jun;8(6):454-64. doi: 10.1111/j.1610-0387.2010.07343.x. Epub 2010 Feb 3.
Photodynamic therapy (PDT) is a modern therapy modality, based upon the application of a photosensitizing agent like aminolevulinic acid, a physiological precursor of porphyrins, onto the tissue followed by illumination with light of the visible wavelength spectrum. During this oxygen-dependent reaction, reactive oxygen species (ROS) are generated that have immunomodulatory or cytotoxic effects. PDT shows excellent cosmetic results especially for its key indication in dermatology - the treatment of non-melanoma skin cancer. The associated pain and the low tissue penetration are the most frequent limiting factors of PDT. We review basic principles and recent developments in photosensitizers and light sources. Key oncological and non-oncological indications are presented as well.
光动力疗法（PDT）是一种现代治疗方法，基于将光敏剂如氨基酮戊酸（ALA），卟啉的生理前体，应用于组织，然后用可见波长光谱的光照射。在这个依赖于氧气的反应中，会产生具有免疫调节或细胞毒性作用的活性氧（ROS）。PDT 显示出极好的美容效果，特别是在皮肤科的主要适应症 - 非黑色素瘤皮肤癌的治疗中。相关的疼痛和低组织穿透性是 PDT 最常见的限制因素。我们回顾了光敏剂和光源的基本原理和最新进展。还介绍了主要的肿瘤学和非肿瘤学适应症。
