Paxillin 表达水平与唾液腺腺样囊性癌的临床分期和转移相关。
Paxillin expression levels are correlated with clinical stage and metastasis in salivary adenoid cystic carcinoma.
机构信息
College of Stomatology, Harbin Medical University, Harbin, Heilongjiang, China.
出版信息
J Oral Pathol Med. 2010 Aug 1;39(7):548-51. doi: 10.1111/j.1600-0714.2009.00859.x. Epub 2010 Jan 28.
AIMS
To investigate the relationship between paxillin expression and clinicopathological features and metastasis in salivary adenoid cystic carcinoma (SACC).
METHODS
A total of 47 SACC were assessed histochemically for paxillin expression. Paxillin immunoreactivity was compared with histological type, clinical stage and distant metastasis.
RESULTS
Paxillin expression was identified in 57.45% of SACC as cytoplasmic staining and the expression was correlated with distant metastasis and clinical stage (P < 0.05), but not with histological type.
CONCLUSIONS
Our observations indicate that paxillin expression is upregulated in SACC. High expression of paxillin was correlated with a more advanced stage and metastasis in SACC, suggesting that paxillin is a disease marker in advanced SACC and SACC with distant metastasis, and, consequently, may have value as a therapeutic target for SACC.
目的
研究桩蛋白表达与唾液腺腺样囊性癌（SACC）临床病理特征及转移的关系。
方法
对 47 例 SACC 进行组织化学检测桩蛋白表达。比较桩蛋白免疫反应与组织学类型、临床分期和远处转移的关系。
结果
SACC 中 57.45%的细胞质染色中检测到桩蛋白表达，其表达与远处转移和临床分期相关（P<0.05），但与组织学类型无关。
结论
我们的观察表明，桩蛋白在 SACC 中呈高表达。桩蛋白的高表达与 SACC 的晚期和转移相关，表明桩蛋白是 SACC 晚期和远处转移的疾病标志物，因此可能作为 SACC 的治疗靶点具有一定价值。
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