阻塞性睡眠呼吸暂停：从发病机制到治疗：当前的争议和未来的方向。
Obstructive Sleep Apnoea: From pathogenesis to treatment: Current controversies and future directions.
机构信息
West Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia.
出版信息
Respirology. 2010 May;15(4):587-95. doi: 10.1111/j.1440-1843.2009.01699.x. Epub 2010 Jan 27.
Abstract
Obstructive sleep apnoea (OSA) is a common disease, recognized as an independent risk factor for a range of clinical conditions, such as hypertension, stroke, depression and diabetes. Despite extensive research over the past two decades, the mechanistic links between OSA and other associated clinical conditions, including metabolic disorders and cardiovascular disease, remain unclear. Indeed, the pathogenesis of OSA itself remains incompletely understood. This review provides opinions from a number of leading experts on issues related to OSA and its pathogenesis, interaction with anaesthesia, metabolic consequences and comorbidities, cardiovascular disease, genetics, measurement and diagnosis, surgical treatment and pharmacotherapeutic targets.
摘要
阻塞性睡眠呼吸暂停（OSA）是一种常见疾病，被认为是一系列临床病症的独立危险因素，如高血压、中风、抑郁和糖尿病。尽管在过去的二十年中进行了广泛的研究，但 OSA 与其他相关临床病症（包括代谢紊乱和心血管疾病）之间的机制联系仍不清楚。事实上，OSA 本身的发病机制仍不完全清楚。本综述提供了一些领先专家对与 OSA 及其发病机制、与麻醉的相互作用、代谢后果和合并症、心血管疾病、遗传学、测量和诊断、手术治疗以及药物治疗靶点相关问题的意见。
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