St. John's Institute of Dermatology, St. Thomas' Hospital, London, UK.
Contact Dermatitis. 2010 Jan;62(1):42-6. doi: 10.1111/j.1600-0536.2009.01658.x.
Patients with chronic actinic dermatitis (CAD) frequently have positive patch or photopatch tests. In our previous study (period 1987-1992), the most prominent contact allergen was the sesquiterpene lactone mix (36% of patients with CAD).
To assess whether contact allergy profiles in CAD patients between 2000 and 2005 have changed in respect to our previous data (1987-1992).
Fifty CAD patient records from 2000 to 2005 for patch and photopatch testing were retrospectively analysed and data were compared with that from 86 patients seen between 1987 and 1992.
Thirty-two (64%) and 64 (74%) patients had positive patch or photopatch tests in 2000-2005 and 1987-1992, respectively. The allergen profile has altered. A decline in sesquiterpene lactone mix positive reactions was noted: 29 (36%) patients were positive in 1987-1992 and 10 (20%) patients in 2000-2005, but this was not significant (P = 0.08). Reactions to non-fragrance consumer allergens (i.e. p-phenylenediamine and preservatives) had risen from 7 reactions (1987-1992) to 21 reactions in 13 individuals (2000-2005) (P < 0.001). Of these allergens, p-phenylenediamine was the most common (12%; P = 0.004).
A significant rise in positive patch tests to non-fragrance consumer allergens, particularly p-phenylenediamine, was seen in CAD patients in 2000-2005. We speculate this alteration of allergen profile may be partly due to changes in exposure patterns.
患有慢性光化性皮炎（CAD）的患者经常出现阳性斑贴或光斑贴试验。在我们之前的研究（1987-1992 年期间）中，最主要的接触过敏原是倍半萜烯混合（36%的 CAD 患者）。
评估 2000 年至 2005 年期间 CAD 患者的接触过敏症谱与我们之前的数据（1987-1992 年）相比是否发生了变化。
回顾性分析了 2000 年至 2005 年期间 50 例 CAD 患者的斑贴和光斑贴试验记录，并将数据与 1987 年至 1992 年期间 86 例患者的数据进行了比较。
2000-2005 年和 1987-1992 年分别有 32 例（64%）和 64 例（74%）患者出现阳性斑贴或光斑贴试验。过敏原谱发生了变化。倍半萜烯混合阳性反应的比例下降：1987-1992 年有 29 例（36%）患者阳性，而 2000-2005 年仅有 10 例（20%）患者阳性，但差异无统计学意义（P=0.08）。非香料消费性过敏原（即对苯二胺和防腐剂）的反应从 7 例（1987-1992 年）增加到 13 例患者中的 21 例（2000-2005 年）（P<0.001）。在这些过敏原中，对苯二胺最常见（12%；P=0.004）。
2000-2005 年 CAD 患者对非香料消费性过敏原，尤其是对苯二胺的阳性斑贴试验显著增加。我们推测，这种过敏原谱的变化可能部分是由于暴露模式的变化所致。
