Charles C. Harris Skin and Cancer Pavilion, Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York 10016, USA.
J Am Acad Dermatol. 2010 Apr;62(4):605-10. doi: 10.1016/j.jaad.2009.06.084. Epub 2010 Feb 16.
Retrospective chart reviews are periodically needed to update allergen series to detect changes in photoallergic contact dermatitis (PACD) over time.
We sought to evaluate photopatch test results during a 13-year period and extend the observations to 20 years.
A retrospective chart review was conducted in patients who were photopatch tested.
In all, 76 patients were evaluated. A total of 69 positive photopatch and 45 positive patch test reactions were detected in 30 and 23 patients, respectively. The frequencies of the positive photopatch test reactions were sunscreens 23.2%, antimicrobial agents 23.2%, medications 20.3%, fragrances 13%, plants and plant derivatives 11.6%, and pesticides 8.7%. Of the positive photopatch reactions to antimicrobial agents, 60% were caused by Fentichlor.
This study was a retrospective chart analysis, and the number of patients was small.
Sunscreens and antimicrobial agents were the most frequent allergens eliciting PACD, and there was a decrease in PACD caused by fragrances. The number of reactions to medications increased. This study also demonstrated that pesticides can be a cause of PACD. The detection of reactions to Fentichlor was unexpected and, although they have been attributed in some studies to cross-reactions to sulfanilamides and bithionol, such a robust association was not observed in this study. This study extends our experience of the changes in the allergens that elicit PACD to 20 years.
为了检测光变应性接触性皮炎（PACD）随时间的变化，需要定期进行回顾性图表审查以更新过敏原系列。
我们旨在评估 13 年期间的光斑贴试验结果，并将观察结果延长至 20 年。
对接受光斑贴试验的患者进行回顾性图表审查。
共评估了 76 例患者。在 30 例和 23 例患者中分别检测到 69 例和 45 例阳性光斑贴和斑贴试验反应。阳性光斑贴试验反应的频率为防晒霜 23.2%、抗菌剂 23.2%、药物 20.3%、香料 13%、植物和植物衍生物 11.6%和杀虫剂 8.7%。抗菌剂引起的阳性光斑贴反应中，有 60%是由非氯苯氧氯酚引起的。
本研究为回顾性图表分析，患者数量较少。
防晒霜和抗菌剂是引起 PACD 的最常见过敏原，而香料引起的 PACD 减少。药物引起的反应数量增加。本研究还表明，杀虫剂也可能是 PACD 的原因。检测到非氯苯氧氯酚的反应出乎意料，尽管在一些研究中归因于磺胺类和双硫仑的交叉反应，但在本研究中未观察到这种强关联。本研究将我们对引起 PACD 的过敏原变化的经验延长至 20 年。
