[农村高血压患者高尿酸血症的患病率及相关危险因素]

[Prevalence and associated risk factors of hyperuricemia in rural hypertensive patients].

作者信息

Fan Xiao-Han, Sun Kai, Wang Yi-Bo, Dang Ai-Min, Zhou Xian-Liang, Zhang Hui-Min, Wu Hai-Ying, Hui Ru-Tai

机构信息

Hypertension Division, Department of Cardiology, Cardiovascular Institute and Fu wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.

出版信息

Zhonghua Yi Xue Za Zhi. 2009 Oct 20;89(38):2667-70.

PMID:20137264

Abstract

OBJECTIVE

To investigate the prevalence of hyperuricemia and its associated risk factors in treated and untreated hypertensive patients in Chinese rural area.

METHODS

This cross-section study was performed in 5235 hypertensive patients aged 40 - 75 years old at Xinyang, Henan by using a multistage cluster sampling method. All patients underwent an investigation composed of a standardized questionnaire, physical and biochemical examination. Hyperuricemia was defined as serum uric acid levels > or = 420 micromol/L in men or > or = 360 micromol/L in women.

RESULTS

The overall prevalence of hyperuricemia was 14.1%, and it was higher in men than in women (21.5% vs 10.2%, P < 0.01). With an increase of body mass index (BMI), the prevalence of hyperuricemia and serum uric acid level increased significantly in both sexes [BMI < 25, > or = 30: 14.4%, 30.4%, (328 +/- 83) micromol/L, (383 +/- 86) micromol/L in males; and 7.2%, 17.0%, (251 +/- 70) micromol/L, (293 +/- 75) micromol/L in females, respectively, all P < 0.01]. So did that with increase of age only in female patients (40 - 49 years vs > or = 70 years: 5.8% - 18.0%, respectively, P < 0.01). Antihypertensive treatment, lipid disorder, smoking and alcohol consumption also significantly increased the incidence of hyperuricemia and the serum uric acid level (all P < 0.01). However, no significant differences were found among patients with I, II, and III blood pressure levels (all P > 0.05). After adjustment for age and other conventional risk factors by using multiple logistic regression analysis, hyperuricemia was significantly associated with BMI, alcohol consumption and diuretics in males as well as BMI, lipid disorder, age, smoking, and antihypertensive treatment in females.

CONCLUSIONS

Hyperuricemia is relatively less common in rural hypertensive patients. The associated risk factors of hyperuricemia and elevated serum uric acids include sex, age, BMI, antihypertensive medicines, lipid disorder, smoking and alcohol consumption. The effect of these factors is different between sexes.

摘要

目的

调查中国农村地区接受治疗和未接受治疗的高血压患者高尿酸血症的患病率及其相关危险因素。

方法

采用多阶段整群抽样方法，对河南省信阳市5235例年龄在40 - 75岁的高血压患者进行了这项横断面研究。所有患者均接受了由标准化问卷、体格检查和生化检查组成的调查。高尿酸血症的定义为男性血清尿酸水平≥420微摩尔/升或女性血清尿酸水平≥360微摩尔/升。

结果

高尿酸血症的总体患病率为14.1%，男性高于女性（21.5%对10.2%，P<0.01）。随着体重指数（BMI）的增加，男女高尿酸血症的患病率和血清尿酸水平均显著升高[男性BMI<25、≥30时：分别为14.4%、30.4%，（328±83）微摩尔/升、（383±86）微摩尔/升；女性分别为7.2%、17.0%，（251±70）微摩尔/升、（293±75）微摩尔/升，均P<0.01]。仅在女性患者中，随着年龄的增加患病率也升高（40 - 49岁对≥70岁：分别为5.8% - 18.0%，P<0.01）。降压治疗、血脂异常、吸烟和饮酒也显著增加高尿酸血症的发病率和血清尿酸水平（均P<0.01）。然而，在血压I、II和III级的患者中未发现显著差异（均P>0.05）。通过多因素logistic回归分析对年龄和其他传统危险因素进行校正后，男性高尿酸血症与BMI、饮酒和利尿剂显著相关，而女性与BMI、血脂异常、年龄、吸烟和降压治疗显著相关。