Department of Clinical Laboratory Medicine, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangzhou, China.
Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangzhou, China.
PLoS One. 2024 Oct 10;19(10):e0306383. doi: 10.1371/journal.pone.0306383. eCollection 2024.
Studies in recent years have shown that high uric acid causes harm to the human body, which has become a serious public health problem. Elevated serum uric acid has been shown to be associated with obesity, but the relationship between BMI and uric acid (UA) remains controversial. Although the association between BMI and UA has been well studied, the effect of phosphorus levels in vivo on this association remains unclear. This study aimed to determine the relationship between BMI and serum uric acid and the effect of phosphorus on the relationship between the two.
The present study analyzed data from the National Health and Nutrition Examination Survey (NHANES) continuous 2007-2018 cycle. We included 10786 participants aged 20 years and over. Multivariable linear regression was performed to assess the association between BMI and serum uric acid. phosphorus was stratified into low phosphorus (<3.3 mg/dl), middle phosphorus (3.3-3.9 mg/dl) and high phosphorus (>3.9 mg/dl). Correction of the effect of phosphorus was assessed by testing the interaction between BMI and UA in multivariate linear regression.
In this cross-sectional study, we found that BMI was positively associated with UA in the female population but not significantly in the male population or in the total population. In multiple regression analysis, UA was 0.51 higher in the highest female BMI group than in the lowest group (p = 0.0001). The relationship between BMI and UA differed significantly by gender under the influence of phosphorus, with men and women in Model II having a greater elevation of UA in men than in women within most groups. (BMI >30, phosphorus >3.9 mg/dl, β:0.83 95% CI: 0.43, 1.23 vs β: 0.79 95% CI: 0.30, 1.29). In addition, phosphorus significantly altered the positive association between BMI and UA in most models.
Our results indicate significant associations between BMI and uric acid in women, with higher BMI values likely to be associated with a higher risk of hyperuricemia, suggesting that uric acid levels in obese people should be closely monitored in clinical practice. Phosphorus and BMI have an interactive effect in elevating UA and should be noted as indicators of phosphorus in clinical practice.
近年来的研究表明，高尿酸会对人体造成伤害，这已成为一个严重的公共卫生问题。已证实血清尿酸升高与肥胖有关，但 BMI 与尿酸（UA）之间的关系仍存在争议。尽管 BMI 与 UA 之间的关系已得到充分研究，但体内磷水平对这种关系的影响尚不清楚。本研究旨在确定 BMI 与血清尿酸之间的关系以及磷对两者关系的影响。
本研究分析了 2007-2018 年全国健康与营养调查（NHANES）连续周期的数据。我们纳入了 10786 名年龄在 20 岁及以上的参与者。采用多元线性回归分析评估 BMI 与血清尿酸之间的关系。将磷分为低磷（<3.3mg/dl）、中磷（3.3-3.9mg/dl）和高磷（>3.9mg/dl）。通过多元线性回归检验 BMI 与 UA 之间的相互作用，评估磷的校正效果。
在这项横断面研究中，我们发现 BMI 与女性人群中的 UA 呈正相关，但在男性人群或总人群中不显著。在多元回归分析中，最高 BMI 组女性的 UA 比最低 BMI 组女性高 0.51（p=0.0001）。在磷的影响下，BMI 与 UA 之间的关系在性别之间存在显著差异，在大多数组中，男性的 UA 升高幅度大于女性（BMI>30，磷>3.9mg/dl，β：0.83 95%CI：0.43，1.23 比β：0.79 95%CI：0.30，1.29）。此外，磷在大多数模型中显著改变了 BMI 与 UA 之间的正相关关系。
我们的结果表明，女性 BMI 与尿酸之间存在显著关联，较高的 BMI 值可能与高尿酸血症风险增加相关，这提示在临床实践中应密切监测肥胖人群的尿酸水平。磷和 BMI 在升高 UA 方面存在交互作用，应作为临床实践中磷的指标加以注意。
