Jia Zhao-tong, Liu Cheng-yu, Li Hong
Department of Endocrinology, The Affiliated Hospital of Medical College of Qingdao University, Qingdao 266003, China.
Zhonghua Yan Ke Za Zhi. 2009 Sep;45(9):805-8.
To explore the changes of the concentration of serum ischemia modified albumin (IMA) and high sensitivity C-reactive protein (hs-CRP) in type 2 diabetic patients with retinopathy (DR).
The concentration of serum IMA and hs-CRP in DR patients were determined by ELISA and rate nephelometry and compared with those in 83 no-DR (NDR) patients and 72 controls. The concentration of serum IMA and hs-CRP in 40 proliferative diabetic retinopathy (PDR) patients were compared with those in 39 no-PDR (NPDR) patients. Data was evaluated using analysis of PPMS version 1.5.Results are expressed as means + or - standard deviation of the mean. Statistical comparisons were performed by student's t-test or one-way analysis of variance followed by Dunnett's multiple comparison test and the means compared each other using q test.
The serum IMA and hs-CRP concentration in DR patients were (46.51 + or - 13.29) microg/L, (4.27 + or - 2.24) mg/L. The serum IMA and hs-CRP concentration in NDR patients were (25.47 + or - 9.33) microg/L, (2.96 + or - 1.84) mg/L. The serum IMA and hs-CRP concentration in controls were (15.36 + or - 4.27) microg/L, (1.86 + or - 0.97) mg/L. The serum IMA and hs-CRP concentration in PDR patients were (54.72 + or - 15.61) microg/L, (6.34 + or - 3.53) mg/L. The serum IMA and hs-CRP concentration in NPDR patients were (38.35 + or - 11.27) microg/L, (3.28 + or - 1.77) mg/L. The serum IMA and hs-CRP concentration were significantly higher in DR patients than those in controls and NDR patients, the serum IMA and hs-CRP concentration in NDR patients were significantly higher than those in controls (F = 197.124, 34.561;q = 5.41-27.34; P < 0.01); the serum IMA and hs-CRP concentration were significantly higher in PDR patients than those in NPDR patients (t = 5.46, 4.89; P < 0.01); there was significant positive correlation between serum IMA concentration and hs-CRP concentration in DR patients (r = 0.617, P < 0.01).
The serum IMA and hs-CRP concentration were significantly high in DR patients, and were positively associated with the seriousness of DR, which may contribute to the development of DR.
探讨2型糖尿病视网膜病变（DR）患者血清缺血修饰白蛋白（IMA）和高敏C反应蛋白（hs-CRP）浓度的变化。
采用酶联免疫吸附测定法（ELISA）和速率散射比浊法测定DR患者血清IMA和hs-CRP浓度，并与83例非糖尿病视网膜病变（NDR）患者及72例对照者进行比较。比较40例增殖性糖尿病视网膜病变（PDR）患者与39例非增殖性糖尿病视网膜病变（NPDR）患者血清IMA和hs-CRP浓度。采用PPMS 1.5版进行数据分析。结果以均值±标准差表示。采用学生t检验或单因素方差分析，随后进行Dunnett多重比较检验，并使用q检验对均值进行相互比较。
DR患者血清IMA和hs-CRP浓度分别为（46.51±13.29）μg/L、（4.27±2.24）mg/L。NDR患者血清IMA和hs-CRP浓度分别为（25.47±9.33）μg/L、（2.96±1.84）mg/L。对照者血清IMA和hs-CRP浓度分别为（15.36±4.27）μg/L、（1.86±0.97）mg/L。PDR患者血清IMA和hs-CRP浓度分别为（54.72±15.61）μg/L、（6.34±3.53）mg/L。NPDR患者血清IMA和hs-CRP浓度分别为（38.35±11.27）μg/L、（3.28±1.77）mg/L。DR患者血清IMA和hs-CRP浓度显著高于对照者和NDR患者，NDR患者血清IMA和hs-CRP浓度显著高于对照者（F=197.124，34.561；q=5.41-27.34；P<0.01）；PDR患者血清IMA和hs-CRP浓度显著高于NPDR患者（t=5.46，4.89；P<0.01）；DR患者血清IMA浓度与hs-CRP浓度呈显著正相关（r=
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