缺血修饰白蛋白、炎症与 2 型糖尿病高血糖的相关性。
Association between ischemia modified albumin, inflammation and hyperglycemia in type 2 diabetes mellitus.
机构信息
Programa de Pós-Graduação em Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.
出版信息
Clin Biochem. 2010 Mar;43(4-5):450-4. doi: 10.1016/j.clinbiochem.2009.11.018. Epub 2009 Dec 5.
OBJECTIVES
The aim of this study was assess serum ischemia modified albumin (IMA) in type 2 diabetes patients and determine its correlation with other risk factors for chronic complications such as inflammation and hyperglycemia.
DESIGN AND METHODS
Fasting glucose, glycated albumin, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, creatinine, uric acid, albumin, lactic acid, high-sensitivity C-reactive protein (hs-CRP) and IMA were measured in 80 patients with type 2 diabetes and 26 controls.
RESULTS
Fasting glucose, glycated albumin, triglycerides, creatinine, IMA and hs-CRP were significantly higher in patients with type 2 diabetes. Correlations were weak but significant between IMA and fasting glucose, IMA and hs-CRP, hs-CRP and HDL cholesterol and hs-CRP and fasting glucose were observed.
CONCLUSIONS
We have shown higher levels of IMA and hs-CRP in type 2 diabetes. Hyperglycemia and inflammation reduces the capacity of albumin to bind cobalt, resulting in higher IMA levels.
目的
本研究旨在评估 2 型糖尿病患者的血清缺血修饰白蛋白（IMA）水平，并确定其与炎症和高血糖等慢性并发症其他危险因素的相关性。
设计和方法
检测 80 例 2 型糖尿病患者和 26 例对照组的空腹血糖、糖化白蛋白、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、甘油三酯、肌酐、尿酸、白蛋白、乳酸、高敏 C 反应蛋白（hs-CRP）和 IMA。
结果
2 型糖尿病患者的空腹血糖、糖化白蛋白、甘油三酯、肌酐、IMA 和 hs-CRP 显著升高。IMA 与空腹血糖、IMA 与 hs-CRP、hs-CRP 与 HDL 胆固醇以及 hs-CRP 与空腹血糖之间存在弱但有统计学意义的相关性。
结论
我们已经证明 2 型糖尿病患者的 IMA 和 hs-CRP 水平升高。高血糖和炎症降低了白蛋白结合钴的能力，导致 IMA 水平升高。
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