Department of Ophthalmology, School of Medicine, Karadeniz Technical University, Trabzon, Turkey.
Retina. 2011 Mar;31(3):602-8. doi: 10.1097/IAE.0b013e3181ed8cd1.
To establish the correlation between ischemia-modified albumin (IMA) and malondialdehyde (MDA) and the development of diabetic retinopathy (DRP) in patients with diabetes mellitus.
Seventy Type 2 diabetic patients, 35 with DRP, and 36 healthy controls were enrolled in this study. Serum IMA and MDA levels were compared statistically. Receiver operating characteristic curve analysis was also performed to calculate the value of IMA and MDA in distinguishing DRP.
Mean serum IMA levels were 0.658 ± 0.128 absorbance units in the non-DRP group, compared with 0.767 ± 0.074 absorbance units in the DRP group and 0.619 ± 0.044 absorbance units in the control group. Mean serum MDA levels were 0.325 ± 0.172 nmol/mL, 0.244 ± 0.152 nmol/mL, and 0.178 ± 0.131 nmol/mL, respectively. The differences in IMA and MDA levels were statistically significant for all groups (P < 0.05 for all). The areas under the receiver operating characteristic curves for the determination of DRP in diabetic patients were 0.789 (95% confidence interval, 0.682-0.896) for IMA and 0.3 (95% confidence interval, 0.175-0.426) for MDA.
Both serum IMA and serum MDA levels were higher in the diabetic patients compared with the control group. In particular, the high sensitivity of IMA toward DRP showed that it reflected retinal vascular complication better than MDA. Ischemia-modified albumin may be a useful marker in monitoring the risk of DRP development.
建立缺血修饰白蛋白（IMA）与丙二醛（MDA）与糖尿病患者糖尿病视网膜病变（DRP）发展的相关性。
本研究纳入了 70 名 2 型糖尿病患者，其中 35 名患有 DRP，36 名健康对照者。对血清 IMA 和 MDA 水平进行了统计学比较。还进行了受试者工作特征曲线分析，以计算 IMA 和 MDA 在区分 DRP 中的价值。
非 DRP 组的平均血清 IMA 水平为 0.658±0.128 吸光度单位，DRP 组为 0.767±0.074 吸光度单位，对照组为 0.619±0.044 吸光度单位。平均血清 MDA 水平分别为 0.325±0.172 nmol/mL、0.244±0.152 nmol/mL 和 0.178±0.131 nmol/mL。各组的 IMA 和 MDA 水平差异均具有统计学意义（均 P<0.05）。IMA 用于确定糖尿病患者 DRP 的受试者工作特征曲线下面积为 0.789（95%置信区间，0.682-0.896），MDA 为 0.3（95%置信区间，0.175-0.426）。
与对照组相比，糖尿病患者的血清 IMA 和 MDA 水平均升高。特别是 IMA 对 DRP 的高灵敏度表明，它比 MDA 更能反映视网膜血管并发症。缺血修饰白蛋白可能是监测 DRP 发展风险的有用标志物。
